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suck abstract from ncbi


10.1177/2324709620963635

http://scihub22266oqcxt.onion/10.1177/2324709620963635
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33019829!7543098!33019829
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suck abstract from ncbi

pmid33019829      J+Investig+Med+High+Impact+Case+Rep 2020 ; 8 (?): 2324709620963635
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  • Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy #MMPMID33019829
  • Malhotra V; Magoon S; Troyer DA; McCune TR
  • J Investig Med High Impact Case Rep 2020[Jan]; 8 (?): 2324709620963635 PMID33019829show ga
  • As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intravenous vitamin C for severe COVID-19 infection. Collapsing FSGS has been described in patients with COVID-19 infection associated with APOL-1; however, this case had collapsing FSGS developing in low-risk heterozygous APOL-1 variant, and we postulate that the intensity of the COVID-19 cytokine storm overwhelmed the protective state of APOL-1 heterozygosity. This case illustrates the importance of assessing the risk and benefit of planned therapeutic interventions on a case-by-case basis especially when there are still so many unknowns in the management of COVID-19 infection. Strong consideration should be given for performing a renal biopsy in patients who develop multifactorial acute kidney injury.
  • |*Betacoronavirus[MESH]
  • |Acute Disease[MESH]
  • |Acute Kidney Injury/diagnosis/etiology[MESH]
  • |Ascorbic Acid/administration & dosage/*adverse effects[MESH]
  • |Biopsy[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology[MESH]
  • |Disease Progression[MESH]
  • |Glomerulosclerosis, Focal Segmental/*chemically induced/diagnosis[MESH]
  • |Humans[MESH]
  • |Hyperoxaluria/*chemically induced/diagnosis/metabolism[MESH]
  • |Injections, Intravenous[MESH]
  • |Kidney Glomerulus/*pathology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Oxalates/*metabolism[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology[MESH]
  • |SARS-CoV-2[MESH]


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