Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1016/j.scitotenv.2020.142436 http://scihub22266oqcxt.onion/10.1016/j.scitotenv.2020.142436 33017762!7518853!33017762     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Total+Environ 2021 ; 755 (Pt 1): 142436 Nephropedia Template TP {{tp|p=33017762|t=2021. Chloroquine commonly induces hormetic dose responses |pdf=|usr=}}{{33017762}} gab.com Text Chloroquine commonly induces hormetic dose responses JO: Sci Total Environ http://www.kidney.de/pget.php?&tw=1&pmid=33017762 #FOAvip The use of chloroquine in the treatment of COVID-19 has received considerable attention. The recent intense focus on this application of chloroquine stimulated an investigation into the effects of chloroquine at low doses on highly biologically-diverse models and whether it may induce hormetic-biphasic dose response effects. The assessment revealed that hormetic effects have been commonly induced by chloroquine, affecting numerous cell types, including tumor cell lines (e.g. human breast and colon) and non-tumor cell lines, enhancing viral replication, sperm motility, various behavioral endpoints as well as decreasing risks of convulsions, and enhancing a spectrum of neuroprotective responses within a preconditioning experimental framework. These diverse and complex findings indicate that hormetic dose responses commonly occur with chloroquine treatment with a range of biological models and endpoints. These findings have implications concerning study design features including the number and spacing of doses, and suggest a range of possible clinical concerns and opportunities depending on the endpoint considered. Twit Text FOAVip Chloroquine commonly induces hormetic dose responses ????Sci Total Environ http://www.kidney.de/pget.php?&tw=1&pmid=33017762 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33017762 #FOAvip English Wikipedia <ref>{{Cite pmid|33017762}}</ref> Chloroquine commonly induces hormetic dose responses #MMPMID33017762 Calabrese EJ; Hanekamp JC; Hanekamp YN; Kapoor R; Dhawan G; Agathokleous E Sci Total Environ 2021[Feb]; 755 (Pt 1): 142436 PMID33017762show ga The use of chloroquine in the treatment of COVID-19 has received considerable attention. The recent intense focus on this application of chloroquine stimulated an investigation into the effects of chloroquine at low doses on highly biologically-diverse models and whether it may induce hormetic-biphasic dose response effects. The assessment revealed that hormetic effects have been commonly induced by chloroquine, affecting numerous cell types, including tumor cell lines (e.g. human breast and colon) and non-tumor cell lines, enhancing viral replication, sperm motility, various behavioral endpoints as well as decreasing risks of convulsions, and enhancing a spectrum of neuroprotective responses within a preconditioning experimental framework. These diverse and complex findings indicate that hormetic dose responses commonly occur with chloroquine treatment with a range of biological models and endpoints. These findings have implications concerning study design features including the number and spacing of doses, and suggest a range of possible clinical concerns and opportunities depending on the endpoint considered. |*COVID-19 Drug Treatment[MESH] |*Chloroquine/pharmacology[MESH] |*Hormesis[MESH] |Dose-Response Relationship, Drug[MESH] |Humans[MESH] |Male[MESH] |SARS-CoV-2[MESH]Chloroquine commonly induces hormetic dose responses (epmc).pdf DeepDyve Pubget Overpricing