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10.1371/journal.pone.0240007 http://scihub22266oqcxt.onion/10.1371/journal.pone.0240007 33017438!7535049!33017438     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2020 ; 15 (10): e0240007 Nephropedia Template TP {{tp|p=33017438|t=2020. Sampling manholes to home in on SARS-CoV-2 infections |pdf=|usr=}}{{33017438}} gab.com Text Sampling manholes to home in on SARS-CoV-2 infections JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33017438 #FOAvip About 50% of individuals infected with the novel Coronavirus (SARS-CoV-2) suffer from intestinal infection as well as respiratory infection. They shed virus in their stool. Municipal sewage systems carry the virus and its genetic remnants. These viral traces can be detected in the sewage entering a wastewater treatment plant (WTP). Such virus signals indicate community infections but not locations of the infection within the community. In this paper, we frame and formulate the problem in a way that leads to algorithmic procedures homing in on locations and/or neighborhoods within the community that are most likely to have infections. Our data source is wastewater sampled and real-time tested from selected manholes. Our algorithms dynamically and adaptively develop a sequence of manholes to sample and test. The algorithms are often finished after 5 to 10 manhole samples, meaning that-in the field-the procedure can be carried out within one day. The goal is to provide timely information that will support faster more productive human testing for viral infection and thus reduce community disease spread. Leveraging the tree graph structure of the sewage system, we develop two algorithms, the first designed for a community that is certified at a given time to have zero infections and the second for a community known to have many infections. For the first, we assume that wastewater at the WTP has just revealed traces of SARS-CoV-2, indicating existence of a "Patient Zero" in the community. This first algorithm identifies the city block in which the infected person resides. For the second, we home in on a most infected neighborhood of the community, where a neighborhood is usually several city blocks. We present extensive computational results, some applied to a small New England city. Twit Text FOAVip Sampling manholes to home in on SARS-CoV-2 infections ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=33017438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33017438 #FOAvip English Wikipedia <ref>{{Cite pmid|33017438}}</ref> Sampling manholes to home in on SARS-CoV-2 infections #MMPMID33017438 Larson RC; Berman O; Nourinejad M PLoS One 2020[]; 15 (10): e0240007 PMID33017438show ga About 50% of individuals infected with the novel Coronavirus (SARS-CoV-2) suffer from intestinal infection as well as respiratory infection. They shed virus in their stool. Municipal sewage systems carry the virus and its genetic remnants. These viral traces can be detected in the sewage entering a wastewater treatment plant (WTP). Such virus signals indicate community infections but not locations of the infection within the community. In this paper, we frame and formulate the problem in a way that leads to algorithmic procedures homing in on locations and/or neighborhoods within the community that are most likely to have infections. Our data source is wastewater sampled and real-time tested from selected manholes. Our algorithms dynamically and adaptively develop a sequence of manholes to sample and test. The algorithms are often finished after 5 to 10 manhole samples, meaning that-in the field-the procedure can be carried out within one day. The goal is to provide timely information that will support faster more productive human testing for viral infection and thus reduce community disease spread. Leveraging the tree graph structure of the sewage system, we develop two algorithms, the first designed for a community that is certified at a given time to have zero infections and the second for a community known to have many infections. For the first, we assume that wastewater at the WTP has just revealed traces of SARS-CoV-2, indicating existence of a "Patient Zero" in the community. This first algorithm identifies the city block in which the infected person resides. For the second, we home in on a most infected neighborhood of the community, where a neighborhood is usually several city blocks. We present extensive computational results, some applied to a small New England city. |*Coronavirus Infections/epidemiology/transmission/virology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/epidemiology/transmission/virology[MESH] |*Residence Characteristics[MESH] |Betacoronavirus/*isolation & purification[MESH] |COVID-19[MESH] |Feces/*virology[MESH] |Humans[MESH] |Massachusetts[MESH] |SARS-CoV-2[MESH]Sampling manholes to home in on SARS-CoV-2 infections (epmc).pdf DeepDyve Pubget Overpricing