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10.15252/emmm.202013105 http://scihub22266oqcxt.onion/10.15252/emmm.202013105 33015938!7646058!33015938     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2021 ; 13 (1): e13105 Nephropedia Template TP {{tp|p=33015938|t=2021. A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2 |pdf=|usr=}}{{33015938}} gab.com Text A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2 JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33015938 #FOAvip The ongoing SARS-CoV-2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses, several advances could be made in the development of treatment strategies against COVID-19. The nucleoside analog remdesivir, which is known for its potent in vitro activity against Ebolavirus and other RNA viruses, was recently shown to reduce the time to recovery in patients with severe COVID-19. It is to date the only approved antiviral for treating COVID-19. Here, we provide a mechanism and evidence-based comparative review of remdesivir and other repurposed drugs with proven in vitro activity against SARS-CoV-2. Twit Text FOAVip A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2 ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=33015938 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33015938 #FOAvip English Wikipedia <ref>{{Cite pmid|33015938}}</ref> A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2 #MMPMID33015938 Simonis A; Theobald SJ; Fatkenheuer G; Rybniker J; Malin JJ EMBO Mol Med 2021[Jan]; 13 (1): e13105 PMID33015938show ga The ongoing SARS-CoV-2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality, and ideally viral transmission. By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses, several advances could be made in the development of treatment strategies against COVID-19. The nucleoside analog remdesivir, which is known for its potent in vitro activity against Ebolavirus and other RNA viruses, was recently shown to reduce the time to recovery in patients with severe COVID-19. It is to date the only approved antiviral for treating COVID-19. Here, we provide a mechanism and evidence-based comparative review of remdesivir and other repurposed drugs with proven in vitro activity against SARS-CoV-2. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning/methods[MESH] |Adenosine Monophosphate/*analogs & derivatives/pharmacology/therapeutic use[MESH] |Alanine/*analogs & derivatives/pharmacology/therapeutic use[MESH] |Amides/pharmacology/therapeutic use[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Benzamidines[MESH] |Esters/pharmacology/therapeutic use[MESH] |Guanidines/pharmacology/therapeutic use[MESH] |Guanine/pharmacology/therapeutic use[MESH] |Humans[MESH] |Indoles/pharmacology/therapeutic use[MESH] |Lopinavir/pharmacology/therapeutic use[MESH] |Protease Inhibitors/pharmacology/therapeutic use[MESH] |Pyrazines/pharmacology/therapeutic use[MESH] |Ribavirin/pharmacology/therapeutic use[MESH] |Ritonavir/pharmacology/therapeutic use[MESH] |SARS-CoV-2/*drug effects/physiology[MESH] |Virus Internalization/drug effects[MESH]A comparative analysis of remdesivir and other repurposed antivirals a(epmc).pdf DeepDyve Pubget Overpricing