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10.1016/j.isci.2020.101611 http://scihub22266oqcxt.onion/10.1016/j.isci.2020.101611 33015591!7518203!33015591     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2020 ; 23 (10): 101611 Nephropedia Template TP {{tp|p=33015591|t=2020. PPARgamma Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19 |pdf=|usr=}}{{33015591}} gab.com Text PPARgamma Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=33015591 #FOAvip The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections are poorly understood. To uncover these events, we performed transcriptome analyses of lung biopsies from patients with COVID-19, revealing a gene enrichment pattern similar to that of PPARgamma-knockout macrophages. Single-cell gene expression analysis of bronchoalveolar lavage fluids revealed a characteristic trajectory of PPARgamma-related disturbance in the CD14+/CD16+ cells. We identified a correlation with the disease severity and the reduced expression of several members of the PPARgamma complex such as EP300, RXRA, RARA, SUMO1, NR3C1, and CCDC88A. ChIP-seq analyses confirmed repression of the PPARgamma-RXRA-NR3C1 cistrome in COVID-19 lung samples. Further analysis of protein-protein networks highlighted an interaction between the PPARgamma-associated protein SUMO1 and a nucleoprotein of the SARS virus. Overall, these results demonstrate for the first time the involvement of the PPARgamma complex in severe COVID-19 lung disease and suggest strongly its role in the major monocyte/macrophage-mediated inflammatory storm. Twit Text FOAVip PPARgamma Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=33015591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33015591 #FOAvip English Wikipedia <ref>{{Cite pmid|33015591}}</ref> PPARgamma Cistrome Repression during Activation of Lung Monocyte-Macrophages in Severe COVID-19 #MMPMID33015591 Desterke C; Turhan AG; Bennaceur-Griscelli A; Griscelli F iScience 2020[Oct]; 23 (10): 101611 PMID33015591show ga The molecular mechanisms of cytokine storm in patients with severe COVID-19 infections are poorly understood. To uncover these events, we performed transcriptome analyses of lung biopsies from patients with COVID-19, revealing a gene enrichment pattern similar to that of PPARgamma-knockout macrophages. Single-cell gene expression analysis of bronchoalveolar lavage fluids revealed a characteristic trajectory of PPARgamma-related disturbance in the CD14+/CD16+ cells. We identified a correlation with the disease severity and the reduced expression of several members of the PPARgamma complex such as EP300, RXRA, RARA, SUMO1, NR3C1, and CCDC88A. ChIP-seq analyses confirmed repression of the PPARgamma-RXRA-NR3C1 cistrome in COVID-19 lung samples. Further analysis of protein-protein networks highlighted an interaction between the PPARgamma-associated protein SUMO1 and a nucleoprotein of the SARS virus. Overall, these results demonstrate for the first time the involvement of the PPARgamma complex in severe COVID-19 lung disease and suggest strongly its role in the major monocyte/macrophage-mediated inflammatory storm. äPPARgamma Cistrome Repression during Activation of Lung Monocyte-Macro(epmc).pdf DeepDyve Pubget Overpricing