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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Appl+Phys+Lett 2020 ; 117 (12): 120601 Nephropedia Template TP
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Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2 #MMPMID33012808
Peng T; Liu X; Adams LG; Agarwal G; Akey B; Cirillo J; Deckert V; Delfan S; Fry E; Han Z; Hemmer P; Kattawar G; Kim M; Lee MC; Lu C; Mogford J; Nessler R; Neuman B; Nie X; Pan J; Pryor J; Rajil N; Shih Y; Sokolov A; Svidzinsky A; Wang D; Yi Z; Zheltikov A; Scully M
Appl Phys Lett 2020[Sep]; 117 (12): 120601 PMID33012808show ga
Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.