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10.1007/s10735-020-09915-3 http://scihub22266oqcxt.onion/10.1007/s10735-020-09915-3 33011887!7533045!33011887     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Histol 2020 ; 51 (6): 613-628 Nephropedia Template TP {{tp|p=33011887|t=2020. COVID-19 and multiorgan failure: A narrative review on potential mechanisms |pdf=|usr=}}{{33011887}} gab.com Text COVID-19 and multiorgan failure: A narrative review on potential mechanisms JO: J Mol Histol http://www.kidney.de/pget.php?&tw=1&pmid=33011887 #FOAvip The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) pandemic. While the common cold symptoms are observed in mild cases, COVID-19 is accompanied by multiorgan failure in severe patients. The involvement of different organs in severe patients results in lengthening the hospitalization duration and increasing the mortality rate. In this review, we aimed to investigate the involvement of different organs in COVID-19 patients, particularly in severe cases. Also, we tried to define the potential underlying mechanisms of SARS-CoV2 induced multiorgan failure. The multi-organ dysfunction is characterized by acute lung failure, acute liver failure, acute kidney injury, cardiovascular disease, and as well as a wide spectrum of hematological abnormalities and neurological disorders. The most important mechanisms are related to the direct and indirect pathogenic features of SARS-CoV2. Although the presence of angiotensin-converting enzyme 2, a receptor of SARS-CoV2 in the lung, heart, kidney, testis, liver, lymphocytes, and nervous system was confirmed, there are controversial findings to about the observation of SARS-CoV2 RNA in these organs. Moreover, the organ failure may be induced by the cytokine storm, a result of increased levels of inflammatory mediators, endothelial dysfunction, coagulation abnormalities, and infiltration of inflammatory cells into the organs. Therefore, further investigations are needed to detect the exact mechanisms of pathogenesis. Since the involvement of several organs in COVID-19 patients is important for clinicians, increasing their knowledge may help to improve the outcomes and decrease the rate of mortality and morbidity. Twit Text FOAVip COVID-19 and multiorgan failure: A narrative review on potential mechanisms ????J Mol Histol http://www.kidney.de/pget.php?&tw=1&pmid=33011887 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33011887 #FOAvip English Wikipedia <ref>{{Cite pmid|33011887}}</ref> COVID-19 and multiorgan failure: A narrative review on potential mechanisms #MMPMID33011887 Mokhtari T; Hassani F; Ghaffari N; Ebrahimi B; Yarahmadi A; Hassanzadeh G J Mol Histol 2020[Dec]; 51 (6): 613-628 PMID33011887show ga The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) pandemic. While the common cold symptoms are observed in mild cases, COVID-19 is accompanied by multiorgan failure in severe patients. The involvement of different organs in severe patients results in lengthening the hospitalization duration and increasing the mortality rate. In this review, we aimed to investigate the involvement of different organs in COVID-19 patients, particularly in severe cases. Also, we tried to define the potential underlying mechanisms of SARS-CoV2 induced multiorgan failure. The multi-organ dysfunction is characterized by acute lung failure, acute liver failure, acute kidney injury, cardiovascular disease, and as well as a wide spectrum of hematological abnormalities and neurological disorders. The most important mechanisms are related to the direct and indirect pathogenic features of SARS-CoV2. Although the presence of angiotensin-converting enzyme 2, a receptor of SARS-CoV2 in the lung, heart, kidney, testis, liver, lymphocytes, and nervous system was confirmed, there are controversial findings to about the observation of SARS-CoV2 RNA in these organs. Moreover, the organ failure may be induced by the cytokine storm, a result of increased levels of inflammatory mediators, endothelial dysfunction, coagulation abnormalities, and infiltration of inflammatory cells into the organs. Therefore, further investigations are needed to detect the exact mechanisms of pathogenesis. Since the involvement of several organs in COVID-19 patients is important for clinicians, increasing their knowledge may help to improve the outcomes and decrease the rate of mortality and morbidity. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology[MESH] |Cytokine Release Syndrome/pathology[MESH] |Heart Diseases/*pathology/virology[MESH] |Humans[MESH] |Kidney Diseases/*pathology/virology[MESH] |Kidney/pathology[MESH] |Liver Diseases/*pathology/virology[MESH] |Liver/pathology[MESH] |Lung/pathology[MESH] |Multiple Organ Failure/*pathology/virology[MESH] |Myocardium/pathology[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*pathology[MESH]COVID-19 and multiorgan failure: A narrative review on potential mecha(epmc).pdf DeepDyve Pubget Overpricing