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10.1038/s41435-020-00112-6 http://scihub22266oqcxt.onion/10.1038/s41435-020-00112-6 33011745!7532735!33011745     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+Immun 2020 ; 21 (5): 360-363 Nephropedia Template TP {{tp|p=33011745|t=2020. Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis |pdf=|usr=}}{{33011745}} gab.com Text Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis JO: Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=33011745 #FOAvip Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease primarily caused by bacteria, viruses have also been implicated in its pathogenesis. Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions. Next, we explored the relationship between the SARS-CoV-2/human interactome and genes expressed in pulpitis. Using existing datasets we show that both ACE2 and TPMRSS2 are expressed in the dental pulp and, that their expression does not change under conditions of inflammation. Furthermore, Master Regulator Analysis of the SARS-CoV2/human interactome identified 75 relevant genes whose expression values are either up-regulated or down-regulated in both the human interactome and pulpitis. Our results suggest that the dental pulp is vulnerable to SARS-CoV2 infection and that SARS-CoV-2 infection of the dental pulp may contribute to worse outcomes of pulpitis. Twit Text FOAVip Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis ????Genes Immun http://www.kidney.de/pget.php?&tw=1&pmid=33011745 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33011745 #FOAvip English Wikipedia <ref>{{Cite pmid|33011745}}</ref> Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis #MMPMID33011745 Galicia JC; Guzzi PH; Giorgi FM; Khan AA Genes Immun 2020[Nov]; 21 (5): 360-363 PMID33011745show ga Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease primarily caused by bacteria, viruses have also been implicated in its pathogenesis. Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions. Next, we explored the relationship between the SARS-CoV-2/human interactome and genes expressed in pulpitis. Using existing datasets we show that both ACE2 and TPMRSS2 are expressed in the dental pulp and, that their expression does not change under conditions of inflammation. Furthermore, Master Regulator Analysis of the SARS-CoV2/human interactome identified 75 relevant genes whose expression values are either up-regulated or down-regulated in both the human interactome and pulpitis. Our results suggest that the dental pulp is vulnerable to SARS-CoV2 infection and that SARS-CoV-2 infection of the dental pulp may contribute to worse outcomes of pulpitis. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/metabolism/virology[MESH] |Datasets as Topic[MESH] |Dental Pulp/*metabolism/virology[MESH] |Gene Expression Profiling[MESH] |Gene Expression Regulation[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Pneumonia, Viral/*complications/metabolism/virology[MESH] |Pulpitis/metabolism/*virology[MESH] |Receptors, Coronavirus[MESH] |Receptors, Virus/metabolism[MESH] |SARS-CoV-2[MESH]Predicting the response of the dental pulp to SARS-CoV2 infection: a (epmc).pdf DeepDyve Pubget Overpricing