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10.1016/j.stem.2020.09.016

http://scihub22266oqcxt.onion/10.1016/j.stem.2020.09.016
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suck abstract from ncbi


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pmid33010822      Cell+Stem+Cell 2020 ; 27 (6): 937-950.e9
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  • Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium #MMPMID33010822
  • Jacob F; Pather SR; Huang WK; Zhang F; Wong SZH; Zhou H; Cubitt B; Fan W; Chen CZ; Xu M; Pradhan M; Zhang DY; Zheng W; Bang AG; Song H; Carlos de la Torre J; Ming GL
  • Cell Stem Cell 2020[Dec]; 27 (6): 937-950.e9 PMID33010822show ga
  • Neurological complications are common in patients with COVID-19. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect brain cells and impact their function is not well understood. Here, we investigated the susceptibility of human induced pluripotent stem cell (hiPSC)-derived monolayer brain cells and region-specific brain organoids to SARS-CoV-2 infection. We found that neurons and astrocytes were sparsely infected, but choroid plexus epithelial cells underwent robust infection. We optimized a protocol to generate choroid plexus organoids from hiPSCs and showed that productive SARS-CoV-2 infection of these organoids is associated with increased cell death and transcriptional dysregulation indicative of an inflammatory response and cellular function deficits. Together, our findings provide evidence for selective SARS-CoV-2 neurotropism and support the use of hiPSC-derived brain organoids as a platform to investigate SARS-CoV-2 infection susceptibility of brain cells, mechanisms of virus-induced brain dysfunction, and treatment strategies.
  • |*Viral Tropism[MESH]
  • |Animals[MESH]
  • |Astrocytes/virology[MESH]
  • |Brain/cytology/virology[MESH]
  • |COVID-19/genetics/virology[MESH]
  • |Cells, Cultured[MESH]
  • |Choroid Plexus/*virology[MESH]
  • |Gene Expression Regulation[MESH]
  • |Humans[MESH]
  • |Neural Stem Cells/*virology[MESH]
  • |Neurons/virology[MESH]
  • |Organoids/*virology[MESH]
  • |Pluripotent Stem Cells/*virology[MESH]


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