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10.1038/s41467-020-18764-3 http://scihub22266oqcxt.onion/10.1038/s41467-020-18764-3 33009401!7532469!33009401     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33009401&cmd=llinks): Failed to open stream: HTTP request failed! 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SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate |pdf=|usr=}}{{33009401}} gab.com Text SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33009401 #FOAvip Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that the NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-OI) and the clinically approved dimethyl fumarate (DMF) induce a cellular antiviral program that potently inhibits replication of SARS-CoV2 across cell lines. The inhibitory effect of 4-OI and DMF extends to the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism. In addition, 4-OI and DMF limit host inflammatory responses to SARS-CoV2 infection associated with airway COVID-19 pathology. In conclusion, NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2. Twit Text FOAVip SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33009401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33009401 #FOAvip English Wikipedia <ref>{{Cite pmid|33009401}}</ref> SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate #MMPMID33009401 Olagnier D; Farahani E; Thyrsted J; Blay-Cadanet J; Herengt A; Idorn M; Hait A; Hernaez B; Knudsen A; Iversen MB; Schilling M; Jorgensen SE; Thomsen M; Reinert LS; Lappe M; Hoang HD; Gilchrist VH; Hansen AL; Ottosen R; Nielsen CG; Moller C; van der Horst D; Peri S; Balachandran S; Huang J; Jakobsen M; Svenningsen EB; Poulsen TB; Bartsch L; Thielke AL; Luo Y; Alain T; Rehwinkel J; Alcami A; Hiscott J; Mogensen TH; Paludan SR; Holm CK Nat Commun 2020[Oct]; 11 (1): 4938 PMID33009401show ga Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we demonstrate that the NRF2 antioxidant gene expression pathway is suppressed in biopsies obtained from COVID-19 patients. Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-OI) and the clinically approved dimethyl fumarate (DMF) induce a cellular antiviral program that potently inhibits replication of SARS-CoV2 across cell lines. The inhibitory effect of 4-OI and DMF extends to the replication of several other pathogenic viruses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interferon (IFN)-independent mechanism. In addition, 4-OI and DMF limit host inflammatory responses to SARS-CoV2 infection associated with airway COVID-19 pathology. In conclusion, NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2. |Adult[MESH] |Anti-Inflammatory Agents/*pharmacology[MESH] |Antioxidants/pharmacology[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects/metabolism[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/virology[MESH] |Dimethyl Fumarate/*agonists/pharmacology[MESH] |Female[MESH] |Gene Expression[MESH] |Gene Knockdown Techniques[MESH] |Humans[MESH] |Interferon Type I[MESH] |Lung/pathology[MESH] |Male[MESH] |NF-E2-Related Factor 2/genetics/*metabolism[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/virology[MESH] |SARS-CoV-2[MESH] |Signal Transduction/drug effects[MESH] |Succinates/*agonists/pharmacology[MESH]SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antivi(epmc).pdf DeepDyve Pubget Overpricing