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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genomics 2021 ; 113 (1 Pt 2): 1221-1232 Nephropedia Template TP
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Genetics and genomics of SARS-CoV-2: A review of the literature with the special focus on genetic diversity and SARS-CoV-2 genome detection #MMPMID33007398
Rahimi A; Mirzazadeh A; Tavakolpour S
Genomics 2021[Jan]; 113 (1 Pt 2): 1221-1232 PMID33007398show ga
The outbreak of 2019-novel coronavirus disease (COVID-19), caused by SARS-CoV-2, started in late 2019; in a short time, it has spread rapidly all over the world. Although some possible antiviral and anti-inflammatory medications are available, thousands of people are dying daily. Well-understanding of the SARS-CoV-2 genome is not only essential for the development of new treatments/vaccines, but it also can be used for improving the sensitivity and specificity of current approaches for virus detection. Accordingly, we reviewed the most critical findings related to the genetics of the SARS-CoV-2, with a specific focus on genetic diversity and reported mutations, molecular-based diagnosis assays, using interfering RNA technology for the treatment of patients, and genetic-related vaccination strategies. Additionally, considering the unanswered questions or uncertainties in these regards, different topics were discussed.
|*Genome, Viral[MESH]
|COVID-19 Nucleic Acid Testing/methods[MESH]
|COVID-19 Vaccines/genetics/pharmacology[MESH]
|COVID-19/diagnosis/therapy/*virology[MESH]
|Genetic Variation[MESH]
|Genomics[MESH]
|Humans[MESH]
|MicroRNAs/genetics/therapeutic use[MESH]
|Molecular Diagnostic Techniques/methods[MESH]
|Mutation[MESH]
|Pandemics[MESH]
|Point-of-Care Testing[MESH]
|RNA Interference[MESH]
|RNA, Small Interfering/genetics/therapeutic use[MESH]