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10.1111/add.15276

http://scihub22266oqcxt.onion/10.1111/add.15276
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33007104!7590402!33007104
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suck abstract from ncbi


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pmid33007104      Addiction 2021 ; 116 (6): 1319-1368
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  • The association of smoking status with SARS-CoV-2 infection, hospitalization and mortality from COVID-19: a living rapid evidence review with Bayesian meta-analyses (version 7) #MMPMID33007104
  • Simons D; Shahab L; Brown J; Perski O
  • Addiction 2021[Jun]; 116 (6): 1319-1368 PMID33007104show ga
  • AIMS: To estimate the association of smoking status with rates of (i) infection, (ii) hospitalization, (iii) disease severity and (iv) mortality from SARS-CoV-2/COVID-19 disease. DESIGN: Living rapid review of observational and experimental studies with random-effects hierarchical Bayesian meta-analyses. Published articles and pre-prints were identified via MEDLINE and medRxiv. SETTING: Community or hospital, no restrictions on location. PARTICIPANTS: Adults who received a SARS-CoV-2 test or a COVID-19 diagnosis. MEASUREMENTS: Outcomes were SARS-CoV-2 infection, hospitalization, disease severity and mortality stratified by smoking status. Study quality was assessed (i.e. 'good', 'fair' and 'poor'). FINDINGS: Version 7 (searches up to 25 August 2020) included 233 studies with 32 'good' and 'fair' quality studies included in meta-analyses. Fifty-seven studies (24.5%) reported current, former and never smoking status. Recorded smoking prevalence among people with COVID-19 was generally lower than national prevalence. Current compared with never smokers were at reduced risk of SARS-CoV-2 infection [relative risk (RR) = 0.74, 95% credible interval (CrI) = 0.58-0.93, tau = 0.41]. Data for former smokers were inconclusive (RR = 1.05, 95% CrI = 0.95-1.17, tau = 0.17), but favoured there being no important association (21% probability of RR >/= 1.1). Former compared with never smokers were at somewhat increased risk of hospitalization (RR = 1.20, CrI = 1.03-1.44, tau = 0.17), greater disease severity (RR = 1.52, CrI = 1.13-2.07, tau = 0.29) and mortality (RR = 1.39, 95% CrI = 1.09-1.87, tau = 0.27). Data for current smokers were inconclusive (RR = 1.06, CrI = 0.82-1.35, tau = 0.27; RR = 1.25, CrI = 0.85-1.93, tau = 0.34; RR = 1.22, 95% CrI = 0.78-1.94, tau = 0.49, respectively), but favoured there being no important associations with hospitalization and mortality (35% and 70% probability of RR >/= 1.1, respectively) and a small but important association with disease severity (79% probability of RR >/= 1.1). CONCLUSIONS: Compared with never smokers, current smokers appear to be at reduced risk of SARS-CoV-2 infection, while former smokers appear to be at increased risk of hospitalization, increased disease severity and mortality from COVID-19. However, it is uncertain whether these associations are causal.
  • |*SARS-CoV-2[MESH]
  • |Bayes Theorem[MESH]
  • |COVID-19/*epidemiology/*mortality[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Mortality[MESH]
  • |Prevalence[MESH]
  • |Risk[MESH]
  • |Severity of Illness Index[MESH]


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