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10.1007/s00705-020-04826-w http://scihub22266oqcxt.onion/10.1007/s00705-020-04826-w 33005986!7529357!33005986     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Virol 2021 ; 166 (1): 35-42 Nephropedia Template TP {{tp|p=33005986|t=2021. Molecular characterization of canine coronaviruses: an enteric and pantropic approach |pdf=|usr=}}{{33005986}} gab.com Text Molecular characterization of canine coronaviruses: an enteric and pantropic approach JO: Arch Virol http://www.kidney.de/pget.php?&tw=1&pmid=33005986 #FOAvip Canine coronavirus (CCoV) generally causes an infection with high morbidity and low mortality in dogs. In recent years, studies on coronaviruses have gained a momentum due to coronavirus outbreaks. Mutations in coronaviruses can result in deadly diseases in new hosts (such as SARS-CoV-2) or cause changes in organ-tissue affinity, as occurred with feline infectious peritonitis virus, exacerbating their pathogenesis. In recent studies on different types of CCoV, the pantropic strains characterized by hypervirulent and multi-systemic infections are believed to be emerging, in contrast to classical enteric coronavirus infections. In this study, we investigated emerging hypervirulent and multi-systemic CCoV strains using molecular and bioinformatic analysis, and examined differences between enteric and pantropic CCoV strains at the phylogenetic level. RT-PCR was performed with specific primers to identify the coronavirus M (membrane) and S (spike) genes, and samples were then subjected to DNA sequencing. In phylogenetic analysis, four out of 26 samples were classified as CCoV-1. The remaining 22 samples were all classified as CCoV-2a. In the CCoV-2a group, six samples were in branches close to enteric strains, and 16 samples were in the branches close to pantropic strains. Enteric and pantropic strains were compared by molecular genotyping of CCoV in dogs. Phylogenetic analysis of hypervirulent pantropic strains was carried out at the amino acid and nucleotide sequence levels. CCoV was found to be divergent from the original strain. This implies that some CCoV strains have become pantropic strains that cause multisystemic infections, and they should not be ruled out as the cause of severe diarrhea and multisystemic infections. Twit Text FOAVip Molecular characterization of canine coronaviruses: an enteric and pantropic approach ????Arch Virol http://www.kidney.de/pget.php?&tw=1&pmid=33005986 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33005986 #FOAvip English Wikipedia <ref>{{Cite pmid|33005986}}</ref> Molecular characterization of canine coronaviruses: an enteric and pantropic approach #MMPMID33005986 Timurkan MO; Aydin H; Dincer E; Coskun N Arch Virol 2021[Jan]; 166 (1): 35-42 PMID33005986show ga Canine coronavirus (CCoV) generally causes an infection with high morbidity and low mortality in dogs. In recent years, studies on coronaviruses have gained a momentum due to coronavirus outbreaks. Mutations in coronaviruses can result in deadly diseases in new hosts (such as SARS-CoV-2) or cause changes in organ-tissue affinity, as occurred with feline infectious peritonitis virus, exacerbating their pathogenesis. In recent studies on different types of CCoV, the pantropic strains characterized by hypervirulent and multi-systemic infections are believed to be emerging, in contrast to classical enteric coronavirus infections. In this study, we investigated emerging hypervirulent and multi-systemic CCoV strains using molecular and bioinformatic analysis, and examined differences between enteric and pantropic CCoV strains at the phylogenetic level. RT-PCR was performed with specific primers to identify the coronavirus M (membrane) and S (spike) genes, and samples were then subjected to DNA sequencing. In phylogenetic analysis, four out of 26 samples were classified as CCoV-1. The remaining 22 samples were all classified as CCoV-2a. In the CCoV-2a group, six samples were in branches close to enteric strains, and 16 samples were in the branches close to pantropic strains. Enteric and pantropic strains were compared by molecular genotyping of CCoV in dogs. Phylogenetic analysis of hypervirulent pantropic strains was carried out at the amino acid and nucleotide sequence levels. CCoV was found to be divergent from the original strain. This implies that some CCoV strains have become pantropic strains that cause multisystemic infections, and they should not be ruled out as the cause of severe diarrhea and multisystemic infections. |Amino Acid Sequence[MESH] |Animals[MESH] |Base Sequence[MESH] |Coronavirus Infections/*pathology/*veterinary[MESH] |Coronavirus, Canine/*genetics/pathogenicity[MESH] |Diarrhea/veterinary/virology[MESH] |Dog Diseases/*pathology/virology[MESH] |Dogs[MESH] |Feces/virology[MESH] |Intestine, Small/virology[MESH] |Mutation/genetics[MESH] |Sequence Analysis, DNA[MESH] |Spike Glycoprotein, Coronavirus/*genetics[MESH] |Turkey[MESH]Molecular characterization of canine coronaviruses: an enteric and pan(epmc).pdf DeepDyve Pubget Overpricing