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10.1097/MCO.0000000000000701 http://scihub22266oqcxt.onion/10.1097/MCO.0000000000000701 33003119!ä!33003119 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Clin+Nutr+Metab+Care 2021 ; 24 (1): 102-107 Nephropedia Template TP {{tp|p=33003119|t=2021. A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019 |pdf=|usr=}}{{33003119}} gab.com Text A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019 JO: Curr Opin Clin Nutr Metab Care http://www.kidney.de/pget.php?&tw=1&pmid=33003119 #FOAvip PURPOSE OF REVIEW: Vitamin D exerts extraskeletal functions, including immunomodulatory activity, protection against respiratory tract infections and pleiotropic effects on the cardiovascular system. Since the outbreak of the coronavirus disease-2019 (COVID-19) pandemic, several articles have suggested the potential involvement of vitamin D in reducing the risk and severity of the disease. RECENT FINDINGS: Epidemiological and observational studies support the hypothesis of a protective role of vitamin D but most studies are retrospective or based on small samples. However, the pandemic progression and the increased knowledge on the pathogenesis of COVID-19 have challenged the first evidence, suggesting also potential negative consequences derived by adequate vitamin D status. A cautious interpretation of the significance of low vitamin D25OH levels is advisable. The balance between over-activation of innate immunity and the exhaustibility of the adaptive immune response still needs to be clarified. In addition, the modulation of endothelial function, the down-regulation of renin, angiotensin-converting-enzyme (ACE) and angiotensin genes and the up-regulation of ACE2 expression is still an area of research. SUMMARY: Speculative hypotheses and observational data have suggested a protective role of vitamin D in COVID-19. However, many unanswered questions remain, aberrant detrimental effects of adequate vitamin D25OH levels cannot be excluded and whether its adequacy may prevent the infection or improve clinical outcomes needs to be assessed by adequately sized and designed population-based studies and intervention trials. Twit Text FOAVip A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019 ????Curr Opin Clin Nutr Metab Care http://www.kidney.de/pget.php?&tw=1&pmid=33003119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33003119 #FOAvip English Wikipedia <ref>{{Cite pmid|33003119}}</ref> A brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019 #MMPMID33003119 Cereda E; Bogliolo L; de Stefano L; Caccialanza R Curr Opin Clin Nutr Metab Care 2021[Jan]; 24 (1): 102-107 PMID33003119show ga PURPOSE OF REVIEW: Vitamin D exerts extraskeletal functions, including immunomodulatory activity, protection against respiratory tract infections and pleiotropic effects on the cardiovascular system. Since the outbreak of the coronavirus disease-2019 (COVID-19) pandemic, several articles have suggested the potential involvement of vitamin D in reducing the risk and severity of the disease. RECENT FINDINGS: Epidemiological and observational studies support the hypothesis of a protective role of vitamin D but most studies are retrospective or based on small samples. However, the pandemic progression and the increased knowledge on the pathogenesis of COVID-19 have challenged the first evidence, suggesting also potential negative consequences derived by adequate vitamin D status. A cautious interpretation of the significance of low vitamin D25OH levels is advisable. The balance between over-activation of innate immunity and the exhaustibility of the adaptive immune response still needs to be clarified. In addition, the modulation of endothelial function, the down-regulation of renin, angiotensin-converting-enzyme (ACE) and angiotensin genes and the up-regulation of ACE2 expression is still an area of research. SUMMARY: Speculative hypotheses and observational data have suggested a protective role of vitamin D in COVID-19. However, many unanswered questions remain, aberrant detrimental effects of adequate vitamin D25OH levels cannot be excluded and whether its adequacy may prevent the infection or improve clinical outcomes needs to be assessed by adequately sized and designed population-based studies and intervention trials. |*Dietary Supplements[MESH] |*Nutritional Status[MESH] |*Severity of Illness Index[MESH] |*Vitamin D/pharmacology/therapeutic use[MESH] |*Vitamins/pharmacology/therapeutic use[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/*complications/epidemiology/prevention & control[MESH] |Endothelium, Vascular[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Renin-Angiotensin System[MESH] |SARS-CoV-2[MESH]A brief discussion of the benefit and mechanism of vitamin D supplemen(epmc).pdf DeepDyve Pubget Overpricing