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10.1016/j.ijcard.2020.09.064

http://scihub22266oqcxt.onion/10.1016/j.ijcard.2020.09.064
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33002521!7521414!33002521
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suck abstract from ncbi

pmid33002521      Int+J+Cardiol 2021 ; 324 (?): 261-266
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  • Antithrombotic therapy in patients with COVID-19? -Rationale and Evidence #MMPMID33002521
  • Godino C; Scotti A; Maugeri N; Mancini N; Fominskiy E; Margonato A; Landoni G
  • Int J Cardiol 2021[Feb]; 324 (?): 261-266 PMID33002521show ga
  • In patients with severe or critical Coronavirus disease 2019 (COVID-19) manifestations, a thromboinflammatory syndrome, with diffuse microvascular thrombosis, is increasingly evident as the final step of pro-inflammatory cytokines storm. Actually, no proven effective therapies for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection exist. Preliminary observations on anticoagulant therapy appear to be associated with better outcomes in moderate and severe COVID-19 patients with signs of coagulopathy and in those requiring mechanical ventilation. The pathophysiology underlying the prothrombotic state elicited by SARS-CoV-2 outlines possible protective mechanisms of antithrombotic therapy (in primis anticoagulants) for this viral illness. The indications for antiplatelet/anticoagulant use (prevention, prophylaxis, therapy) are guided by the clinical context and the COVID-19 severity. We provide a practical approach on antithrombotic therapy management for COVID-19 patients from a multidisciplinary point of view.
  • |*COVID-19 Drug Treatment[MESH]
  • |Anticoagulants/therapeutic use[MESH]
  • |COVID-19/*blood/physiopathology[MESH]
  • |Evidence-Based Medicine/*trends[MESH]
  • |Fibrinolytic Agents/*therapeutic use[MESH]
  • |Humans[MESH]


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