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10.7554/eLife.59633 http://scihub22266oqcxt.onion/10.7554/eLife.59633 33001029!7655111!33001029     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=33001029|t=2020. Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic |pdf=|usr=}}{{33001029}} gab.com Text Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=33001029 #FOAvip Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with pandemics but are still widely overlooked. We identify and characterize ORF3d, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not other closely related pangolin-CoVs or bat-CoVs. We then document evidence of ORF3d translation, characterize its protein sequence, and conduct an evolutionary analysis at three levels: between taxa (21 members of Severe acute respiratory syndrome-related coronavirus), between human hosts (3978 SARS-CoV-2 consensus sequences), and within human hosts (401 deeply sequenced SARS-CoV-2 samples). ORF3d has been independently identified and shown to elicit a strong antibody response in COVID-19 patients. However, it has been misclassified as the unrelated gene ORF3b, leading to confusion. Our results liken ORF3d to other accessory genes in emerging viruses and highlight the importance of OLGs. Twit Text FOAVip Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=33001029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33001029 #FOAvip English Wikipedia <ref>{{Cite pmid|33001029}}</ref> Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic #MMPMID33001029 Nelson CW; Ardern Z; Goldberg TL; Meng C; Kuo CH; Ludwig C; Kolokotronis SO; Wei X Elife 2020[Oct]; 9 (ä): ä PMID33001029show ga Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with pandemics but are still widely overlooked. We identify and characterize ORF3d, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not other closely related pangolin-CoVs or bat-CoVs. We then document evidence of ORF3d translation, characterize its protein sequence, and conduct an evolutionary analysis at three levels: between taxa (21 members of Severe acute respiratory syndrome-related coronavirus), between human hosts (3978 SARS-CoV-2 consensus sequences), and within human hosts (401 deeply sequenced SARS-CoV-2 samples). ORF3d has been independently identified and shown to elicit a strong antibody response in COVID-19 patients. However, it has been misclassified as the unrelated gene ORF3b, leading to confusion. Our results liken ORF3d to other accessory genes in emerging viruses and highlight the importance of OLGs. |*Evolution, Molecular[MESH] |*Genes, Overlapping[MESH] |*Genes, Viral[MESH] |*Pandemics[MESH] |Amino Acid Sequence[MESH] |Animals[MESH] |Antibodies, Viral/immunology[MESH] |Antibody Specificity[MESH] |Antigens, Viral/biosynthesis/genetics/immunology[MESH] |Betacoronavirus/*genetics/pathogenicity/physiology[MESH] |COVID-19[MESH] |China/epidemiology[MESH] |Chiroptera/virology[MESH] |Coronavirus Infections/epidemiology/*virology[MESH] |Coronavirus/genetics[MESH] |Epitopes/genetics/immunology[MESH] |Europe/epidemiology[MESH] |Eutheria/virology[MESH] |Gene Expression Regulation, Viral[MESH] |Genetic Variation[MESH] |Haplotypes/genetics[MESH] |Host Specificity/*genetics[MESH] |Humans[MESH] |Models, Molecular[MESH] |Mutation[MESH] |Open Reading Frames/*genetics[MESH] |Phylogeny[MESH] |Pneumonia, Viral/epidemiology/*virology[MESH] |Protein Biosynthesis[MESH] |Protein Conformation[MESH] |RNA, Viral/genetics[MESH] |SARS-CoV-2[MESH] |Sequence Alignment[MESH] |Sequence Homology, Nucleic Acid[MESH]Dynamically evolving novel overlapping gene as a factor in the SARS-Co(epmc).pdf DeepDyve Pubget Overpricing