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10.1093/ofid/ofaa375 http://scihub22266oqcxt.onion/10.1093/ofid/ofaa375 32999893!7499767!32999893     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Open+Forum+Infect+Dis 2020 ; 7 (9): ofaa375 Nephropedia Template TP {{tp|p=32999893|t=2020. Fever Patterns, Cytokine Profiles, and Outcomes in COVID-19 |pdf=|usr=}}{{32999893}} gab.com Text Fever Patterns, Cytokine Profiles, and Outcomes in COVID-19 JO: Open Forum Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32999893 #FOAvip BACKGROUND: Prolonged fever is associated with adverse outcomes in dengue viral infection. Similar fever patterns are observed in COVID-19 with unclear significance. METHODS: We conducted a hospital-based case-control study of patients admitted for COVID-19 with prolonged fever (fever >7 days) and saddleback fever (recurrence of fever, lasting <24 hours, after defervescence beyond day 7 of illness). Fever was defined as a temperature of >/=38.0 degrees C. Cytokines were determined with multiplex microbead-based immunoassay for a subgroup of patients. Adverse outcomes were hypoxia, intensive care unit (ICU) admission, mechanical ventilation, and mortality. RESULTS: A total of 142 patients were included in the study; 12.7% (18/142) of cases had prolonged fever, and 9.9% (14/142) had saddleback fever. Those with prolonged fever had a median duration of fever (interquartile range [IQR]) of 10 (9-11) days for prolonged fever cases, while fever recurred at a median (IQR) of 10 (8-12) days for those with saddleback fever. Both prolonged (27.8% vs 0.9%; P < .01) and saddleback fever (14.3% vs 0.9%; P = .03) were associated with hypoxia compared with controls. Cases with prolonged fever were also more likely to require ICU admission compared with controls (11.1% vs 0.9%; P = .05). Patients with prolonged fever had higher induced protein-10 and lower interleukin-1alpha levels compared with those with saddleback fever at the early acute phase of disease. CONCLUSIONS: Prolonged fever beyond 7 days from onset of illness can identify patients who may be at risk of adverse outcomes from COVID-19. Patients with saddleback fever appeared to have good outcomes regardless of the fever. Twit Text FOAVip Fever Patterns, Cytokine Profiles, and Outcomes in COVID-19 ????Open Forum Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32999893 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32999893 #FOAvip English Wikipedia <ref>{{Cite pmid|32999893}}</ref> Fever Patterns, Cytokine Profiles, and Outcomes in COVID-19 #MMPMID32999893 Ng DHL; Choy CY; Chan YH; Young BE; Fong SW; Ng LFP; Renia L; Lye DC; Chia PY Open Forum Infect Dis 2020[Sep]; 7 (9): ofaa375 PMID32999893show ga BACKGROUND: Prolonged fever is associated with adverse outcomes in dengue viral infection. Similar fever patterns are observed in COVID-19 with unclear significance. METHODS: We conducted a hospital-based case-control study of patients admitted for COVID-19 with prolonged fever (fever >7 days) and saddleback fever (recurrence of fever, lasting <24 hours, after defervescence beyond day 7 of illness). Fever was defined as a temperature of >/=38.0 degrees C. Cytokines were determined with multiplex microbead-based immunoassay for a subgroup of patients. Adverse outcomes were hypoxia, intensive care unit (ICU) admission, mechanical ventilation, and mortality. RESULTS: A total of 142 patients were included in the study; 12.7% (18/142) of cases had prolonged fever, and 9.9% (14/142) had saddleback fever. Those with prolonged fever had a median duration of fever (interquartile range [IQR]) of 10 (9-11) days for prolonged fever cases, while fever recurred at a median (IQR) of 10 (8-12) days for those with saddleback fever. Both prolonged (27.8% vs 0.9%; P < .01) and saddleback fever (14.3% vs 0.9%; P = .03) were associated with hypoxia compared with controls. Cases with prolonged fever were also more likely to require ICU admission compared with controls (11.1% vs 0.9%; P = .05). Patients with prolonged fever had higher induced protein-10 and lower interleukin-1alpha levels compared with those with saddleback fever at the early acute phase of disease. CONCLUSIONS: Prolonged fever beyond 7 days from onset of illness can identify patients who may be at risk of adverse outcomes from COVID-19. Patients with saddleback fever appeared to have good outcomes regardless of the fever. äFever Patterns, Cytokine Profiles, and Outcomes in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing