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10.1038/s41590-020-00808-x http://scihub22266oqcxt.onion/10.1038/s41590-020-00808-x 32999467!ä!32999467 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32999467&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2021 ; 22 (1): 74-85 Nephropedia Template TP {{tp|p=32999467|t=2021. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition |pdf=|usr=}}{{32999467}} gab.com Text SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32999467 #FOAvip T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of exact viral T cell epitopes is fundamental. Here we identify and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals. SARS-CoV-2-specific peptides enabled detection of post-infectious T cell immunity, even in seronegative convalescent individuals. Cross-reactive SARS-CoV-2 peptides revealed pre-existing T cell responses in 81% of unexposed individuals and validated similarity with common cold coronaviruses, providing a functional basis for heterologous immunity in SARS-CoV-2 infection. Diversity of SARS-CoV-2 T cell responses was associated with mild symptoms of COVID-19, providing evidence that immunity requires recognition of multiple epitopes. Together, the proposed SARS-CoV-2 T cell epitopes enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures for COVID-19. Twit Text FOAVip SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32999467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32999467 #FOAvip English Wikipedia <ref>{{Cite pmid|32999467}}</ref> SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition #MMPMID32999467 Nelde A; Bilich T; Heitmann JS; Maringer Y; Salih HR; Roerden M; Lubke M; Bauer J; Rieth J; Wacker M; Peter A; Horber S; Traenkle B; Kaiser PD; Rothbauer U; Becker M; Junker D; Krause G; Strengert M; Schneiderhan-Marra N; Templin MF; Joos TO; Kowalewski DJ; Stos-Zweifel V; Fehr M; Rabsteyn A; Mirakaj V; Karbach J; Jager E; Graf M; Gruber LC; Rachfalski D; Preuss B; Hagelstein I; Marklin M; Bakchoul T; Gouttefangeas C; Kohlbacher O; Klein R; Stevanovic S; Rammensee HG; Walz JS Nat Immunol 2021[Jan]; 22 (1): 74-85 PMID32999467show ga T cell immunity is central for the control of viral infections. To characterize T cell immunity, but also for the development of vaccines, identification of exact viral T cell epitopes is fundamental. Here we identify and characterize multiple dominant and subdominant SARS-CoV-2 HLA class I and HLA-DR peptides as potential T cell epitopes in COVID-19 convalescent and unexposed individuals. SARS-CoV-2-specific peptides enabled detection of post-infectious T cell immunity, even in seronegative convalescent individuals. Cross-reactive SARS-CoV-2 peptides revealed pre-existing T cell responses in 81% of unexposed individuals and validated similarity with common cold coronaviruses, providing a functional basis for heterologous immunity in SARS-CoV-2 infection. Diversity of SARS-CoV-2 T cell responses was associated with mild symptoms of COVID-19, providing evidence that immunity requires recognition of multiple epitopes. Together, the proposed SARS-CoV-2 T cell epitopes enable identification of heterologous and post-infectious T cell immunity and facilitate development of diagnostic, preventive and therapeutic measures for COVID-19. |COVID-19/*immunology/prevention & control/virology[MESH] |Cross Reactions/immunology[MESH] |Epitopes, T-Lymphocyte/*immunology[MESH] |HLA-DR Antigens/immunology/metabolism[MESH] |Histocompatibility Antigens Class I/immunology/metabolism[MESH] |Humans[MESH] |Immunologic Memory/immunology[MESH] |Peptides/*immunology[MESH] |SARS-CoV-2/*immunology/physiology[MESH] |T-Lymphocytes/*immunology/metabolism[MESH]SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T(epmc).pdf DeepDyve Pubget Overpricing