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Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Sci+Rep 2020 ; 10 (1): 16099 Nephropedia Template TP
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Ultrastructural analysis of SARS-CoV-2 interactions with the host cell via high resolution scanning electron microscopy #MMPMID32999356
Caldas LA; Carneiro FA; Higa LM; Monteiro FL; da Silva GP; da Costa LJ; Durigon EL; Tanuri A; de Souza W
Sci Rep 2020[Sep]; 10 (1): 16099 PMID32999356show ga
SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Here, we investigated the interaction of this new coronavirus with Vero cells using high resolution scanning electron microscopy. Surface morphology, the interior of infected cells and the distribution of viral particles in both environments were observed 2 and 48 h after infection. We showed areas of viral processing, details of vacuole contents, and viral interactions with the cell surface. Intercellular connections were also approached, and viral particles were adhered to these extensions suggesting direct cell-to-cell transmission of SARS-CoV-2.