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10.1038/s41586-020-2818-3

http://scihub22266oqcxt.onion/10.1038/s41586-020-2818-3
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32998156!ä!32998156

suck abstract from ncbi


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pmid32998156      Nature 2020 ; 587 (7835): 610-612
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  • The major genetic risk factor for severe COVID-19 is inherited from Neanderthals #MMPMID32998156
  • Zeberg H; Paabo S
  • Nature 2020[Nov]; 587 (7835): 610-612 PMID32998156show ga
  • A recent genetic association study(1) identified a gene cluster on chromosome 3 as a risk locus for respiratory failure after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A separate study (COVID-19 Host Genetics Initiative)(2) comprising 3,199 hospitalized patients with coronavirus disease 2019 (COVID-19) and control individuals showed that this cluster is the major genetic risk factor for severe symptoms after SARS-CoV-2 infection and hospitalization. Here we show that the risk is conferred by a genomic segment of around 50 kilobases in size that is inherited from Neanderthals and is carried by around 50% of people in south Asia and around 16% of people in Europe.
  • |*Genetic Predisposition to Disease[MESH]
  • |Animals[MESH]
  • |Asia/ethnology[MESH]
  • |COVID-19/complications/*genetics/*physiopathology[MESH]
  • |Case-Control Studies[MESH]
  • |Chromosomes, Human, Pair 3/genetics[MESH]
  • |Europe/ethnology[MESH]
  • |Genetic Variation/genetics[MESH]
  • |Genome-Wide Association Study[MESH]
  • |Haplotypes/genetics[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Linkage Disequilibrium/genetics[MESH]
  • |Multigene Family/genetics[MESH]
  • |Neanderthals/*genetics[MESH]
  • |Phylogeny[MESH]


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