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10.1093/ecco-jcc/jjaa201 http://scihub22266oqcxt.onion/10.1093/ecco-jcc/jjaa201 32997749!7543345!32997749     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Crohns+Colitis 2021 ; 15 (4): 687-691 Nephropedia Template TP {{tp|p=32997749|t=2021. Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 PIMS-TS in a Patient Receiving Infliximab Therapy for Inflammatory Bowel Disease |pdf=|usr=}}{{32997749}} gab.com Text Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 PIMS-TS in a Patient Receiving Infliximab Therapy for Inflammatory Bowel Disease JO: J Crohns Colitis http://www.kidney.de/pget.php?&tw=1&pmid=32997749 #FOAvip Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 [PIMS-TS] is a newly described condition. It has a spectrum of presentations proposed to occur as part of a post-infectious immune response. We report the first case of PIMS-TS in a child on established anti-tumour necrosis factor alpha [anti-TNFalpha] therapy; a 10 year-old girl with ulcerative colitis treated with infliximab. The patient had 6 weeks of daily fever with mucocutaneous, gastrointestinal, renal, and haematological involvement. Biomarkers of hyperinflammation were present including: hyperferritinaemia [up to 691 micro/L; normal 15-80 microg/L], C-reactive protein [CRP] [ >100mg/L for >10 days, normal 0-5 mg/L], erythrocyte sedimentation rate [ESR] consistently >100mm/h [normal 0-15 mm/h], raised white cell count with neutrophilia, elevated D-dimer and lactate dehydrogenase [LDH], anaemia and Mott cells on bone marrow analysis. Extensive investigations for alternative diagnoses for pyrexia of unknown origin [PUO] were negative. The condition was refractory to treatment with intravenous immunoglobulin [IVIG] but improved within 24 h of high-dose methylprednisolone. Infliximab treatment followed and the patient has remained well at follow-up. Polymerase chain reaction [PCR] and serology for SARS-CoV-2 were negative. Current series report such negative findings in up to half of cases. The patient experienced a milder clinical phenotype without cardiac involvement, shock, or organ failure. Accepting the wide spectrum of PIMS-TS presentations, it is possible that previous anti-TNFalpha therapy may have attenuated the disease course. Given the uncertainty around therapeutic strategies for PIMS-TS, this case supports the need for further investigation into continuing infliximab as a treatment option for the condition. Twit Text FOAVip Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 PIMS-TS in a Patient Receiving Infliximab Therapy for Inflammatory Bowel Disease ????J Crohns Colitis http://www.kidney.de/pget.php?&tw=1&pmid=32997749 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32997749 #FOAvip English Wikipedia <ref>{{Cite pmid|32997749}}</ref> Paediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 PIMS-TS in a Patient Receiving Infliximab Therapy for Inflammatory Bowel Disease #MMPMID32997749 Meredith J; Khedim CA; Henderson P; Wilson DC; Russell RK J Crohns Colitis 2021[Apr]; 15 (4): 687-691 PMID32997749show ga Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 [PIMS-TS] is a newly described condition. It has a spectrum of presentations proposed to occur as part of a post-infectious immune response. We report the first case of PIMS-TS in a child on established anti-tumour necrosis factor alpha [anti-TNFalpha] therapy; a 10 year-old girl with ulcerative colitis treated with infliximab. The patient had 6 weeks of daily fever with mucocutaneous, gastrointestinal, renal, and haematological involvement. Biomarkers of hyperinflammation were present including: hyperferritinaemia [up to 691 micro/L; normal 15-80 microg/L], C-reactive protein [CRP] [ >100mg/L for >10 days, normal 0-5 mg/L], erythrocyte sedimentation rate [ESR] consistently >100mm/h [normal 0-15 mm/h], raised white cell count with neutrophilia, elevated D-dimer and lactate dehydrogenase [LDH], anaemia and Mott cells on bone marrow analysis. Extensive investigations for alternative diagnoses for pyrexia of unknown origin [PUO] were negative. The condition was refractory to treatment with intravenous immunoglobulin [IVIG] but improved within 24 h of high-dose methylprednisolone. Infliximab treatment followed and the patient has remained well at follow-up. Polymerase chain reaction [PCR] and serology for SARS-CoV-2 were negative. Current series report such negative findings in up to half of cases. The patient experienced a milder clinical phenotype without cardiac involvement, shock, or organ failure. Accepting the wide spectrum of PIMS-TS presentations, it is possible that previous anti-TNFalpha therapy may have attenuated the disease course. Given the uncertainty around therapeutic strategies for PIMS-TS, this case supports the need for further investigation into continuing infliximab as a treatment option for the condition. |COVID-19/complications/*diagnosis/therapy[MESH] |Child[MESH] |Colitis, Ulcerative/complications/*drug therapy[MESH] |Female[MESH] |Gastrointestinal Agents/*therapeutic use[MESH] |Humans[MESH] |Infliximab/*therapeutic use[MESH]Paediatric Inflammatory Multisystem Syndrome Temporally Associated Wit(epmc).pdf DeepDyve Pubget Overpricing