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10.1371/journal.pcbi.1008238 http://scihub22266oqcxt.onion/10.1371/journal.pcbi.1008238 32997660!7561109!32997660     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Comput+Biol 2020 ; 16 (9): e1008238 Nephropedia Template TP {{tp|p=32997660|t=2020. IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis |pdf=|usr=}}{{32997660}} gab.com Text IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis JO: PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=32997660 #FOAvip During these days of global emergency for the COVID-19 disease outbreak, there is an urgency to share reliable information able to help worldwide life scientists to get better insights and make sense of the large amount of data currently available. In this study we used the results presented in [1] to perform two different Systems Biology analyses on the HCoV-host interactome. In the first one, we reconstructed the interactome of the HCoV-host proteins, integrating it with highly reliable miRNA and drug interactions information. We then added the IL-6 gene, identified in recent publications [2] as heavily involved in the COVID-19 progression and, interestingly, we identified several interactions with the reconstructed interactome. In the second analysis, we performed a Gene Ontology and a Pathways enrichment analysis on the full set of the HCoV-host interactome proteins and on the ones belonging to a significantly dense cluster of interacting proteins identified in the first analysis. Results of the two analyses provide a compact but comprehensive glance on some of the current state-of-the-art regulations, GO, and pathways involved in the HCoV-host interactome, and that could support all scientists currently focusing on SARS-CoV-2 research. Twit Text FOAVip IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis ????PLoS Comput Biol http://www.kidney.de/pget.php?&tw=1&pmid=32997660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32997660 #FOAvip English Wikipedia <ref>{{Cite pmid|32997660}}</ref> IL6-mediated HCoV-host interactome regulatory network and GO/Pathway enrichment analysis #MMPMID32997660 Politano G; Benso A PLoS Comput Biol 2020[Sep]; 16 (9): e1008238 PMID32997660show ga During these days of global emergency for the COVID-19 disease outbreak, there is an urgency to share reliable information able to help worldwide life scientists to get better insights and make sense of the large amount of data currently available. In this study we used the results presented in [1] to perform two different Systems Biology analyses on the HCoV-host interactome. In the first one, we reconstructed the interactome of the HCoV-host proteins, integrating it with highly reliable miRNA and drug interactions information. We then added the IL-6 gene, identified in recent publications [2] as heavily involved in the COVID-19 progression and, interestingly, we identified several interactions with the reconstructed interactome. In the second analysis, we performed a Gene Ontology and a Pathways enrichment analysis on the full set of the HCoV-host interactome proteins and on the ones belonging to a significantly dense cluster of interacting proteins identified in the first analysis. Results of the two analyses provide a compact but comprehensive glance on some of the current state-of-the-art regulations, GO, and pathways involved in the HCoV-host interactome, and that could support all scientists currently focusing on SARS-CoV-2 research. |*Gene Ontology[MESH] |*Host-Pathogen Interactions[MESH] |Betacoronavirus/genetics/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*virology[MESH] |Genes, Viral[MESH] |Humans[MESH] |Interleukin-6/*physiology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*virology[MESH] |SARS-CoV-2[MESH]IL6-mediated HCoV-host interactome regulatory network and GO/Pathway e(epmc).pdf DeepDyve Pubget Overpricing