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10.1172/JCI143380

http://scihub22266oqcxt.onion/10.1172/JCI143380
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32997649!7773342!32997649
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suck abstract from ncbi


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pmid32997649      J+Clin+Invest 2021 ; 131 (1): ä
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  • Recent endemic coronavirus infection is associated with less-severe COVID-19 #MMPMID32997649
  • Sagar M; Reifler K; Rossi M; Miller NS; Sinha P; White LF; Mizgerd JP
  • J Clin Invest 2021[Jan]; 131 (1): ä PMID32997649show ga
  • Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.
  • |*SARS-CoV-2[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Antibodies, Viral/*blood[MESH]
  • |COVID-19/*blood/*epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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