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10.1152/ajplung.00391.2020 http://scihub22266oqcxt.onion/10.1152/ajplung.00391.2020 32996784!7789973!32996784     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Lung+Cell+Mol+Physiol 2020 ; 319 (5): L843-L847 Nephropedia Template TP {{tp|p=32996784|t=2020. Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?|pdf=|usr=}}{{32996784}} gab.com Text Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19 JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32996784 #FOAvip The incidence, severity, and mortality of ongoing coronavirus infectious disease 19 (COVID-19) is greater in men compared with women, but the underlying factors contributing to this sex difference are still being explored. In the current study, using primary isolated human airway smooth muscle (ASM) cells from normal males versus females as a model, we explored the effect of estrogen versus testosterone in modulating the expression of angiotensin converting enzyme 2 (ACE2), a cell entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using confocal imaging, we found that ACE2 is expressed in human ASM. Furthermore, Western analysis of ASM cell lysates showed significantly lower ACE2 expression in females compared with males at baseline. In addition, ASM cells exposed to estrogen and testosterone for 24 h showed that testosterone significantly upregulates ACE2 expression in both males and females, whereas estrogen downregulates ACE2, albeit not significant compared with vehicle. These intrinsic and sex steroids induced differences may help explain sex differences in COVID-19. Twit Text FOAVip Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19 ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32996784 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32996784 #FOAvip English Wikipedia <ref>{{Cite pmid|32996784}}</ref> Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19? #MMPMID32996784 Kalidhindi RSR; Borkar NA; Ambhore NS; Pabelick CM; Prakash YS; Sathish V Am J Physiol Lung Cell Mol Physiol 2020[Nov]; 319 (5): L843-L847 PMID32996784show ga The incidence, severity, and mortality of ongoing coronavirus infectious disease 19 (COVID-19) is greater in men compared with women, but the underlying factors contributing to this sex difference are still being explored. In the current study, using primary isolated human airway smooth muscle (ASM) cells from normal males versus females as a model, we explored the effect of estrogen versus testosterone in modulating the expression of angiotensin converting enzyme 2 (ACE2), a cell entry point for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using confocal imaging, we found that ACE2 is expressed in human ASM. Furthermore, Western analysis of ASM cell lysates showed significantly lower ACE2 expression in females compared with males at baseline. In addition, ASM cells exposed to estrogen and testosterone for 24 h showed that testosterone significantly upregulates ACE2 expression in both males and females, whereas estrogen downregulates ACE2, albeit not significant compared with vehicle. These intrinsic and sex steroids induced differences may help explain sex differences in COVID-19. |Adult[MESH] |Aged[MESH] |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/enzymology/*metabolism[MESH] |Estrogens/metabolism/pharmacology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Myocytes, Smooth Muscle/cytology/drug effects/enzymology/metabolism[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*biosynthesis/metabolism[MESH] |Pneumonia, Viral/enzymology/*metabolism[MESH] |Respiratory System/cytology/drug effects/enzymology/*metabolism[MESH] |Sex Factors[MESH]Sex steroids skew ACE2 expression in human airway: a contributing fact(epmc).pdf DeepDyve Pubget Overpricing