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10.4269/ajtmh.20-0954 http://scihub22266oqcxt.onion/10.4269/ajtmh.20-0954 32996443!7646800!32996443     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Trop+Med+Hyg 2020 ; 103 (5): 2019-2021 Nephropedia Template TP {{tp|p=32996443|t=2020. Is Higher Viral Load in SARS-CoV-2 Associated with Death?|pdf=|usr=}}{{32996443}} gab.com Text Is Higher Viral Load in SARS-CoV-2 Associated with Death JO: Am J Trop Med Hyg http://www.kidney.de/pget.php?&tw=1&pmid=32996443 #FOAvip There is no proven prognostic marker for patients hospitalized with COVID-19. We conducted a retrospective cohort study of patients hospitalized with COVID-19 from March 14, 2020 to June 17, 2020, at Sao Paulo Hospital, in Sao Paulo, Brazil. SARS-CoV-2 viral load was assessed using the cycle threshold (Ct) values obtained from a reverse transcription-PCR assay applied to the nasopharyngeal swab samples. The reactions were performed following the CDC U.S. protocol targeting the N1 and N2 sequences of the SARS-CoV-2 nucleoprotein gene and human ribonuclease P gene serving as an endogenous control. Disease severity and patient outcomes were compared. Among 875 patients, 50.1% (439/875) were categorized as having mild disease (nonhospitalized patients), 30.4% (266/875) moderate (hospitalized in the ward), and 19.5% (170/875) severe disease (admitted to the intensive care unit). A Ct value of < 25 (472/875) indicated a high viral load, which was independently associated with mortality (odds ratio [OR]: 2.93; 95% CI: 1.87-4.60; P < 0.0001). We concluded that admission SARS-CoV-2 viral load was independently associated with mortality among patients hospitalized with COVID-19. Twit Text FOAVip Is Higher Viral Load in SARS-CoV-2 Associated with Death ????Am J Trop Med Hyg http://www.kidney.de/pget.php?&tw=1&pmid=32996443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32996443 #FOAvip English Wikipedia <ref>{{Cite pmid|32996443}}</ref> Is Higher Viral Load in SARS-CoV-2 Associated with Death? #MMPMID32996443 Faico-Filho KS; Passarelli VC; Bellei N Am J Trop Med Hyg 2020[Nov]; 103 (5): 2019-2021 PMID32996443show ga There is no proven prognostic marker for patients hospitalized with COVID-19. We conducted a retrospective cohort study of patients hospitalized with COVID-19 from March 14, 2020 to June 17, 2020, at Sao Paulo Hospital, in Sao Paulo, Brazil. SARS-CoV-2 viral load was assessed using the cycle threshold (Ct) values obtained from a reverse transcription-PCR assay applied to the nasopharyngeal swab samples. The reactions were performed following the CDC U.S. protocol targeting the N1 and N2 sequences of the SARS-CoV-2 nucleoprotein gene and human ribonuclease P gene serving as an endogenous control. Disease severity and patient outcomes were compared. Among 875 patients, 50.1% (439/875) were categorized as having mild disease (nonhospitalized patients), 30.4% (266/875) moderate (hospitalized in the ward), and 19.5% (170/875) severe disease (admitted to the intensive care unit). A Ct value of < 25 (472/875) indicated a high viral load, which was independently associated with mortality (odds ratio [OR]: 2.93; 95% CI: 1.87-4.60; P < 0.0001). We concluded that admission SARS-CoV-2 viral load was independently associated with mortality among patients hospitalized with COVID-19. |*Viral Load[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |Brazil[MESH] |COVID-19[MESH] |Child[MESH] |Child, Preschool[MESH] |Coronavirus Infections/*mortality[MESH] |Female[MESH] |Hospitalization[MESH] |Humans[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*mortality[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]Is Higher Viral Load in SARS-CoV-2 Associated with Death?(epmc).pdf DeepDyve Pubget Overpricing