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10.1016/j.obmed.2020.100303 http://scihub22266oqcxt.onion/10.1016/j.obmed.2020.100303 32995660!7513689!32995660     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Obes+Med 2020 ; 20 (ä): 100303 Nephropedia Template TP {{tp|p=32995660|t=2020. Single cell sequencing unraveling genetic basis of severe COVID19 in obesity |pdf=|usr=}}{{32995660}} gab.com Text Single cell sequencing unraveling genetic basis of severe COVID19 in obesity JO: Obes Med http://www.kidney.de/pget.php?&tw=1&pmid=32995660 #FOAvip COVID-19 has shown a substantial variation in the rate and severity by which it impacts different demographic groups. Specifically, it has shown a predilection towards obese patients as well as well as other vulnerable groups including predilection of males over females, old age over young age and black races over Caucasian ones. Single cell sequencing studies have highlighted the role of cell polarity and the co-expression of proteases, such as Furin, along with ACE2 in the genesis of coronavirus disease rather than exclusively link tissue involvement with ACE2 levels thought previously. It has also forged a connection between the genetic and immune cellular mechanisms underlying COVID infection and the inflammatory state of obese patients, offering a more accurate explanation as to why obese patients are at increased risk of poor COVID outcomes. These commonalities encompass macrophage phenotype switching, genetic expression switching, and overexpression of the pro-inflammatory cytokines, depletion of the regulatory cytokines, in situ T cell proliferation, and T cell exhaustion. These findings demonstrate the necessity of single cell sequencing as a rapid means to identify and treat those who are most likely to need hospital admission and intensive care, in the hopes of precision medicine. Furthermore, this study underlines the use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one. Twit Text FOAVip Single cell sequencing unraveling genetic basis of severe COVID19 in obesity ????Obes Med http://www.kidney.de/pget.php?&tw=1&pmid=32995660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32995660 #FOAvip English Wikipedia <ref>{{Cite pmid|32995660}}</ref> Single cell sequencing unraveling genetic basis of severe COVID19 in obesity #MMPMID32995660 AbdelMassih AF; Fouda R; Kamel A; Mishriky F; Ismail HA; El Qadi L; Malak L; Mohamed M; Arsanyous M; Hazem M; El-Husseiny M; Ashraf M; Hafez N; AlShehry N; El-Husseiny N; AbdelRaouf N; Shebl N; Hafez N; Youssef N; Afdal P; Hozaien R; Menshawey R; Saeed R; Yasser R; Hesham S; Zakarriah W; Khattab S; Elammary Y; Ye J Obes Med 2020[Dec]; 20 (ä): 100303 PMID32995660show ga COVID-19 has shown a substantial variation in the rate and severity by which it impacts different demographic groups. Specifically, it has shown a predilection towards obese patients as well as well as other vulnerable groups including predilection of males over females, old age over young age and black races over Caucasian ones. Single cell sequencing studies have highlighted the role of cell polarity and the co-expression of proteases, such as Furin, along with ACE2 in the genesis of coronavirus disease rather than exclusively link tissue involvement with ACE2 levels thought previously. It has also forged a connection between the genetic and immune cellular mechanisms underlying COVID infection and the inflammatory state of obese patients, offering a more accurate explanation as to why obese patients are at increased risk of poor COVID outcomes. These commonalities encompass macrophage phenotype switching, genetic expression switching, and overexpression of the pro-inflammatory cytokines, depletion of the regulatory cytokines, in situ T cell proliferation, and T cell exhaustion. These findings demonstrate the necessity of single cell sequencing as a rapid means to identify and treat those who are most likely to need hospital admission and intensive care, in the hopes of precision medicine. Furthermore, this study underlines the use of immune modulators such as Leptin sensitizers, rather than immune suppressors as anti-inflammation therapies to switch the inflammatory response from a drastic immunological type 1 response to a beneficial type 2 effective one. äSingle cell sequencing unraveling genetic basis of severe COVID19 in o(epmc).pdf DeepDyve Pubget Overpricing