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10.1126/science.abd4250 http://scihub22266oqcxt.onion/10.1126/science.abd4250 32994364!7857405!32994364     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2020 ; 370 (6520): ä Nephropedia Template TP {{tp|p=32994364|t=2020. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity |pdf=|usr=}}{{32994364}} gab.com Text Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=32994364 #FOAvip Understanding humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics, therapeutics, and vaccines. Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) patients and 190 pre-COVID-19 era controls using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies. Preexisting antibodies in controls recognized SARS-CoV-2 ORF1, whereas only COVID-19 patient antibodies primarily recognized spike protein and nucleoprotein. A machine learning model trained on VirScan data predicted SARS-CoV-2 exposure history with 99% sensitivity and 98% specificity; a rapid Luminex-based diagnostic was developed from the most discriminatory SARS-CoV-2 peptides. Individuals with more severe COVID-19 exhibited stronger and broader SARS-CoV-2 responses, weaker antibody responses to prior infections, and higher incidence of cytomegalovirus and herpes simplex virus 1, possibly influenced by demographic covariates. Among hospitalized patients, males produce stronger SARS-CoV-2 antibody responses than females. Twit Text FOAVip Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity ????Science http://www.kidney.de/pget.php?&tw=1&pmid=32994364 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32994364 #FOAvip English Wikipedia <ref>{{Cite pmid|32994364}}</ref> Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity #MMPMID32994364 Shrock E; Fujimura E; Kula T; Timms RT; Lee IH; Leng Y; Robinson ML; Sie BM; Li MZ; Chen Y; Logue J; Zuiani A; McCulloch D; Lelis FJN; Henson S; Monaco DR; Travers M; Habibi S; Clarke WA; Caturegli P; Laeyendecker O; Piechocka-Trocha A; Li JZ; Khatri A; Chu HY; Villani AC; Kays K; Goldberg MB; Hacohen N; Filbin MR; Yu XG; Walker BD; Wesemann DR; Larman HB; Lederer JA; Elledge SJ Science 2020[Nov]; 370 (6520): ä PMID32994364show ga Understanding humoral responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for improving diagnostics, therapeutics, and vaccines. Deep serological profiling of 232 coronavirus disease 2019 (COVID-19) patients and 190 pre-COVID-19 era controls using VirScan revealed more than 800 epitopes in the SARS-CoV-2 proteome, including 10 epitopes likely recognized by neutralizing antibodies. Preexisting antibodies in controls recognized SARS-CoV-2 ORF1, whereas only COVID-19 patient antibodies primarily recognized spike protein and nucleoprotein. A machine learning model trained on VirScan data predicted SARS-CoV-2 exposure history with 99% sensitivity and 98% specificity; a rapid Luminex-based diagnostic was developed from the most discriminatory SARS-CoV-2 peptides. Individuals with more severe COVID-19 exhibited stronger and broader SARS-CoV-2 responses, weaker antibody responses to prior infections, and higher incidence of cytomegalovirus and herpes simplex virus 1, possibly influenced by demographic covariates. Among hospitalized patients, males produce stronger SARS-CoV-2 antibody responses than females. |*Epitope Mapping[MESH] |*Severity of Illness Index[MESH] |Antibodies, Neutralizing/blood/immunology[MESH] |Antibody Formation[MESH] |COVID-19 Serological Testing[MESH] |COVID-19/blood/*immunology[MESH] |Cross Reactions[MESH] |Cryoelectron Microscopy[MESH] |Epitopes/chemistry/genetics/*immunology[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |Protein Conformation[MESH] |SARS-CoV-2/*immunology[MESH]Viral epitope profiling of COVID-19 patients reveals cross-reactivity (epmc).pdf DeepDyve Pubget Overpricing