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10.1186/s12911-020-01266-z

http://scihub22266oqcxt.onion/10.1186/s12911-020-01266-z
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suck abstract from ncbi


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pmid32993652      BMC+Med+Inform+Decis+Mak 2020 ; 20 (1): 247
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  • Using machine learning of clinical data to diagnose COVID-19: a systematic review and meta-analysis #MMPMID32993652
  • Li WT; Ma J; Shende N; Castaneda G; Chakladar J; Tsai JC; Apostol L; Honda CO; Xu J; Wong LM; Zhang T; Lee A; Gnanasekar A; Honda TK; Kuo SZ; Yu MA; Chang EY; Rajasekaran MR; Ongkeko WM
  • BMC Med Inform Decis Mak 2020[Sep]; 20 (1): 247 PMID32993652show ga
  • BACKGROUND: The recent Coronavirus Disease 2019 (COVID-19) pandemic has placed severe stress on healthcare systems worldwide, which is amplified by the critical shortage of COVID-19 tests. METHODS: In this study, we propose to generate a more accurate diagnosis model of COVID-19 based on patient symptoms and routine test results by applying machine learning to reanalyzing COVID-19 data from 151 published studies. We aim to investigate correlations between clinical variables, cluster COVID-19 patients into subtypes, and generate a computational classification model for discriminating between COVID-19 patients and influenza patients based on clinical variables alone. RESULTS: We discovered several novel associations between clinical variables, including correlations between being male and having higher levels of serum lymphocytes and neutrophils. We found that COVID-19 patients could be clustered into subtypes based on serum levels of immune cells, gender, and reported symptoms. Finally, we trained an XGBoost model to achieve a sensitivity of 92.5% and a specificity of 97.9% in discriminating COVID-19 patients from influenza patients. CONCLUSIONS: We demonstrated that computational methods trained on large clinical datasets could yield ever more accurate COVID-19 diagnostic models to mitigate the impact of lack of testing. We also presented previously unknown COVID-19 clinical variable correlations and clinical subgroups.
  • |*Machine Learning[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/*methods[MESH]
  • |Computer Simulation[MESH]
  • |Coronavirus Infections/classification/*diagnosis[MESH]
  • |Datasets as Topic[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Influenza A virus[MESH]
  • |Influenza, Human/*diagnosis[MESH]
  • |Male[MESH]
  • |Pandemics/classification[MESH]
  • |Pneumonia, Viral/classification/*diagnosis[MESH]
  • |SARS-CoV-2[MESH]


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