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10.3390/pathogens9100785 http://scihub22266oqcxt.onion/10.3390/pathogens9100785 32992810!7600722!32992810     free     free     free       Pathogens 2020 ; 9 (10): ä Nephropedia Template TP {{tp|p=32992810|t=2020. Endothelial Cell Contributions to COVID-19 |pdf=|usr=}}{{32992810}} gab.com Text Endothelial Cell Contributions to COVID-19 JO: Pathogens http://www.kidney.de/pget.php?&tw=1&pmid=32992810 #FOAvip Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has remained elusive. Coronavirus disease 2019 (COVID-19) caused by this virus has unusual clinical presentation with regard to other related coronaviruses. Recent reports suggest that SARS-CoV-2, unlike other related viruses, infects and replicates within endothelial cells, which may explain a significant portion of the observed clinical pathology. Likewise, mounting evidence associates vascular and endothelial cell dysfunction with increased mortality. This review focuses on understanding how endothelial cell pathology is caused by SARS-CoV-2 at the molecular and cellular levels and how these events relate to COVID-19. A detailed examination of current knowledge regarding canonical inflammatory reaction pathways as well as alteration of endothelial cell-derived exosomes and transdifferentiation by SARS-CoV-2 is included in this assessment. Additionally, given an understanding of endothelial contributions to COVID-19, potential therapeutic aims are discussed, particularly as would affect endothelial function and pathology. Twit Text FOAVip Endothelial Cell Contributions to COVID-19 ????Pathogens http://www.kidney.de/pget.php?&tw=1&pmid=32992810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32992810 #FOAvip English Wikipedia <ref>{{Cite pmid|32992810}}</ref> Endothelial Cell Contributions to COVID-19 #MMPMID32992810 Oxford AE; Halla F; Robertson EB; Morrison BE Pathogens 2020[Sep]; 9 (10): ä PMID32992810show ga Understanding of the clinical, histological and molecular features of the novel coronavirus 2019 (Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)) has remained elusive. Coronavirus disease 2019 (COVID-19) caused by this virus has unusual clinical presentation with regard to other related coronaviruses. Recent reports suggest that SARS-CoV-2, unlike other related viruses, infects and replicates within endothelial cells, which may explain a significant portion of the observed clinical pathology. Likewise, mounting evidence associates vascular and endothelial cell dysfunction with increased mortality. This review focuses on understanding how endothelial cell pathology is caused by SARS-CoV-2 at the molecular and cellular levels and how these events relate to COVID-19. A detailed examination of current knowledge regarding canonical inflammatory reaction pathways as well as alteration of endothelial cell-derived exosomes and transdifferentiation by SARS-CoV-2 is included in this assessment. Additionally, given an understanding of endothelial contributions to COVID-19, potential therapeutic aims are discussed, particularly as would affect endothelial function and pathology. äEndothelial Cell Contributions to COVID-19 (epmc).pdf DeepDyve Pubget Overpricing