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10.1016/j.amjcard.2020.09.029

http://scihub22266oqcxt.onion/10.1016/j.amjcard.2020.09.029
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32991860!7521434!32991860
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suck abstract from ncbi


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pmid32991860      Am+J+Cardiol 2020 ; 137 (ä): 111-117
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  • Mortality Risk Assessment Using CHA(2)DS(2)-VASc Scores in Patients Hospitalized With Coronavirus Disease 2019 Infection #MMPMID32991860
  • Ruocco G; McCullough PA; Tecson KM; Mancone M; De Ferrari GM; D'Ascenzo F; De Rosa FG; Paggi A; Forleo G; Secco GG; Pistis G; Monticone S; Vicenzi M; Rota I; Blasi F; Pugliese F; Fedele F; Palazzuoli A
  • Am J Cardiol 2020[Dec]; 137 (ä): 111-117 PMID32991860show ga
  • Early risk stratification for complications and death related to Coronavirus disease 2019 (COVID-19) infection is needed. Because many patients with COVID-19 who developed acute respiratory distress syndrome have diffuse alveolar inflammatory damage associated with microvessel thrombosis, we aimed to investigate a common clinical tool, the CHA(2)DS(2)-VASc, to aid in the prognostication of outcomes for COVID-19 patients. We analyzed consecutive patients from the multicenter observational CORACLE registry, which contains data of patients hospitalized for COVID-19 infection in 4 regions of Italy, according to data-driven tertiles of CHA(2)DS(2)-VASc score. The primary outcomes were inpatient death and a composite of inpatient death or invasive ventilation. Of 1045 patients in the registry, 864 (82.7%) had data available to calculate CHA(2)DS(2)-VASc score and were included in the analysis. Of these, 167 (19.3%) died, 123 (14.2%) received invasive ventilation, and 249 (28.8%) had the composite outcome. Stratification by CHA(2)DS(2)-VASc tertiles (T1: /=4) revealed increases in both death (8.1%, 24.3%, 33.3%, respectively; p <0.001) and the composite end point (18.6%, 31.9%, 43.5%, respectively; p <0.001). The odds ratios for mortality and the composite end point for T2 patients versus T1 CHA(2)DS(2)-VASc score were 3.62 (95% CI:2.29 to 5.73,p <0.001) and 2.04 (95% CI:1.42 to 2.93, p <0.001), respectively. Similarly, the odds ratios for mortality and the composite end point for T3 patients versus T1 were 5.65 (95% CI:3.54 to 9.01, p <0.001) and 3.36 (95% CI:2.30 to 4.90,p <0.001), respectively. In conclusion, among Italian patients hospitalized for COVID-19 infection, the CHA(2)DS(2)-VASc risk score for thromboembolic events enhanced the ability to achieve risk stratification for complications and death.
  • |*Hospital Mortality[MESH]
  • |Age Factors[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19/*mortality/therapy[MESH]
  • |Diabetes Mellitus/*epidemiology[MESH]
  • |Female[MESH]
  • |Heart Failure/*epidemiology[MESH]
  • |Hospitalization[MESH]
  • |Humans[MESH]
  • |Hypertension/*epidemiology[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Myocardial Ischemia/*epidemiology[MESH]
  • |Odds Ratio[MESH]
  • |Prognosis[MESH]
  • |Registries[MESH]
  • |Respiration, Artificial/*statistics & numerical data[MESH]
  • |Risk Assessment[MESH]
  • |Sex Factors[MESH]


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