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10.1016/j.cell.2020.09.034 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.09.034 32991843!7489877!32991843     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (4): 982-995.e14 Nephropedia Template TP {{tp|p=32991843|t=2020. Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C) |pdf=|usr=}}{{32991843}} gab.com Text Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C) JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32991843 #FOAvip Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with intact neutralization capability. Cytokine profiling identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28). Immunophenotyping of peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes, suggesting extravasation to affected tissues. Finally, profiling the autoantigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal, and immune-cell antigens. All patients were treated with anti-IL-6R antibody and/or IVIG, which led to rapid disease resolution. Twit Text FOAVip Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C) ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32991843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32991843 #FOAvip English Wikipedia <ref>{{Cite pmid|32991843}}</ref> Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C) #MMPMID32991843 Gruber CN; Patel RS; Trachtman R; Lepow L; Amanat F; Krammer F; Wilson KM; Onel K; Geanon D; Tuballes K; Patel M; Mouskas K; O'Donnell T; Merritt E; Simons NW; Barcessat V; Del Valle DM; Udondem S; Kang G; Gangadharan S; Ofori-Amanfo G; Laserson U; Rahman A; Kim-Schulze S; Charney AW; Gnjatic S; Gelb BD; Merad M; Bogunovic D Cell 2020[Nov]; 183 (4): 982-995.e14 PMID32991843show ga Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with intact neutralization capability. Cytokine profiling identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28). Immunophenotyping of peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes, suggesting extravasation to affected tissues. Finally, profiling the autoantigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal, and immune-cell antigens. All patients were treated with anti-IL-6R antibody and/or IVIG, which led to rapid disease resolution. |Adolescent[MESH] |Antibodies, Viral/blood[MESH] |Autoantibodies/blood[MESH] |Betacoronavirus/immunology/isolation & purification[MESH] |COVID-19[MESH] |Chemokine CCL3/metabolism[MESH] |Child[MESH] |Child, Preschool[MESH] |Coronavirus Infections/complications/pathology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Humoral[MESH] |Infant[MESH] |Infant, Newborn[MESH] |Inflammation/metabolism/*pathology[MESH] |Interleukin-17/metabolism[MESH] |Interleukin-18/metabolism[MESH] |Killer Cells, Natural/cytology/metabolism[MESH] |Male[MESH] |Pandemics[MESH] |Pneumonia, Viral/complications/pathology/virology[MESH] |SARS-CoV-2[MESH] |Systemic Inflammatory Response Syndrome/immunology/metabolism/*pathology[MESH] |T-Lymphocytes/cytology/metabolism[MESH]Mapping Systemic Inflammation and Antibody Responses in Multisystem In(epmc).pdf DeepDyve Pubget Overpricing