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10.1371/journal.ppat.1008870 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1008870 32991634!7546498!32991634     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2020 ; 16 (9): e1008870 Nephropedia Template TP {{tp|p=32991634|t=2020. Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells |pdf=|usr=}}{{32991634}} gab.com Text Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=32991634 #FOAvip The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors. Both transcription factors share a great degree of homology based on sequence analysis and as a result exert partial functional redundancy during viral infection. However, the actual degree of redundancy between T-bet and Eomes remains a matter of debate and is further confounded by their distinct spatiotemporal expression pattern in activated CD8 T cells. To directly investigate the functional overlap of these transcription factors, we generated a new mouse model in which Eomes expression is under the transcriptional control of the endogenous Tbx21 (encoding for T-bet) locus. Applying this model, we demonstrate that the induction of Eomes in lieu of T-bet cannot rescue T-bet deficiency in CD8 T cells during acute lymphocytic choriomeningitis virus (LCMV) infection. We found that the expression of Eomes instead of T-bet was not sufficient for early cell expansion or effector cell differentiation. Finally, we show that imposed expression of Eomes after acute viral infection promotes some features of exhaustion but must act in concert with other factors during chronic viral infection to establish all hallmarks of exhaustion. In summary, our results clearly underline the importance of T-bet in guiding canonical CTL development during acute viral infections. Twit Text FOAVip Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=32991634 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32991634 #FOAvip English Wikipedia <ref>{{Cite pmid|32991634}}</ref> Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells #MMPMID32991634 Fixemer J; Hummel JF; Arnold F; Klose CSN; Hofherr A; Weissert K; Kogl T; Kottgen M; Arnold SJ; Aichele P; Tanriver Y PLoS Pathog 2020[Sep]; 16 (9): e1008870 PMID32991634show ga The two T-box transcription factors T-bet and Eomesodermin (Eomes) are important regulators of cytotoxic lymphocytes (CTLs), such as activated CD8 T cells, which are essential in the fight against intracellular pathogens and tumors. Both transcription factors share a great degree of homology based on sequence analysis and as a result exert partial functional redundancy during viral infection. However, the actual degree of redundancy between T-bet and Eomes remains a matter of debate and is further confounded by their distinct spatiotemporal expression pattern in activated CD8 T cells. To directly investigate the functional overlap of these transcription factors, we generated a new mouse model in which Eomes expression is under the transcriptional control of the endogenous Tbx21 (encoding for T-bet) locus. Applying this model, we demonstrate that the induction of Eomes in lieu of T-bet cannot rescue T-bet deficiency in CD8 T cells during acute lymphocytic choriomeningitis virus (LCMV) infection. We found that the expression of Eomes instead of T-bet was not sufficient for early cell expansion or effector cell differentiation. Finally, we show that imposed expression of Eomes after acute viral infection promotes some features of exhaustion but must act in concert with other factors during chronic viral infection to establish all hallmarks of exhaustion. In summary, our results clearly underline the importance of T-bet in guiding canonical CTL development during acute viral infections. |Animals[MESH] |CD8-Positive T-Lymphocytes/*metabolism[MESH] |Cell Differentiation/*physiology[MESH] |Cell Proliferation[MESH] |Cells, Cultured[MESH] |Fetal Proteins/metabolism[MESH] |Gene Expression Regulation/physiology[MESH] |Interferon-gamma/metabolism[MESH] |Mice, Transgenic[MESH]Eomes cannot replace its paralog T-bet during expansion and differenti(epmc).pdf DeepDyve Pubget Overpricing