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Deprecated: Implicit conversion from float 205.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Asian+Pac+J+Allergy+Immunol 2020 ; 38 (3): 170-177 Nephropedia Template TP
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COVID-19 in children: Heterogeneity within the disease and hypothetical pathogenesis #MMPMID32990448
Suratannon N; Dik WA; Chatchatee P; Hagen PMV
Asian Pac J Allergy Immunol 2020[Sep]; 38 (3): 170-177 PMID32990448show ga
The disease course of coronavirus disease 2019 (COVID-19) is usually mild and self-limiting in previously healthy children, but they may also develop severe disease. Severe COVID-19 infection is especially observed in very young children or those with underlying comorbidities. Moreover, a multisystem inflammatory syndrome that mimics the Kawasaki disease shock syndrome can develop in children that are genetically predisposed to displaying an overactive immune response to SARS-CoV-2 infection. In this review, we describe the clinical phenotypes of mild and severe COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We also discuss the possible immunobiological mechanisms that may be involved in the protection of children against COVID-19 and the development of multisystem inflammatory syndrome.
Asian+Pac+J+Allergy+Immunol 2020 ; 38 (3): 170-177
