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10.1007/s12026-020-09156-2 http://scihub22266oqcxt.onion/10.1007/s12026-020-09156-2 32989677!7521864!32989677     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunol+Res 2020 ; 68 (6): 398-404 Nephropedia Template TP {{tp|p=32989677|t=2020. Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2 |pdf=|usr=}}{{32989677}} gab.com Text Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2 JO: Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=32989677 #FOAvip This single-center, retrospective study aimed to explore the immune characteristics of COVID-19 and biomarkers to predict the severity of this disease. Patients infected with SARS-CoV-2 (n = 215) treated at the First Affiliated Hospital of Nanchang University from January 24 to March 12, 2020, were included in the study and classified into severe and non-severe groups. Peripheral immunocyte count and cytokine statuses were compared. The correlation between immune status, cytokine levels, and disease severity was analyzed. Leukocyte numbers were normal in both groups; however, they were relatively high (7.19 x 10(9)/L) in patients of the severe group. Leukocyte distributions differed between the two groups; the severe group had a higher percentage of neutrophils and lower percentage of lymphocytes compared with the non-severe group, and absolute lymphocyte numbers were below normal in both groups, and particularly deficient in patients in the severe group. Lymphocyte counts have negative correlation with duration of hospital period whereas neutrophil count has no significant correlation with it. Of tested cytokines, IL-6 levels were significantly higher in the severe group (P = 0.0418). Low level of lymphocyte predicts severity of COVID-19. IL-6 levels were significantly higher in the severe group, especially in some extremely severe patients. But we did not detect the significant correlation between severity of COVID-19 with IL-6 level which may be due to limited case numbers. Our observations encourage future research to understand the underlying molecular mechanisms and to improve treatment outcome of COVID-19. Twit Text FOAVip Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2 ????Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=32989677 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32989677 #FOAvip English Wikipedia <ref>{{Cite pmid|32989677}}</ref> Immune characteristics distinguish patients with severe disease associated with SARS-CoV-2 #MMPMID32989677 Li X; Liu Y; Li J; Sun L; Yang J; Xu F; Zhou J; Wan L; Xu X; Le A; Zhang W Immunol Res 2020[Dec]; 68 (6): 398-404 PMID32989677show ga This single-center, retrospective study aimed to explore the immune characteristics of COVID-19 and biomarkers to predict the severity of this disease. Patients infected with SARS-CoV-2 (n = 215) treated at the First Affiliated Hospital of Nanchang University from January 24 to March 12, 2020, were included in the study and classified into severe and non-severe groups. Peripheral immunocyte count and cytokine statuses were compared. The correlation between immune status, cytokine levels, and disease severity was analyzed. Leukocyte numbers were normal in both groups; however, they were relatively high (7.19 x 10(9)/L) in patients of the severe group. Leukocyte distributions differed between the two groups; the severe group had a higher percentage of neutrophils and lower percentage of lymphocytes compared with the non-severe group, and absolute lymphocyte numbers were below normal in both groups, and particularly deficient in patients in the severe group. Lymphocyte counts have negative correlation with duration of hospital period whereas neutrophil count has no significant correlation with it. Of tested cytokines, IL-6 levels were significantly higher in the severe group (P = 0.0418). Low level of lymphocyte predicts severity of COVID-19. IL-6 levels were significantly higher in the severe group, especially in some extremely severe patients. But we did not detect the significant correlation between severity of COVID-19 with IL-6 level which may be due to limited case numbers. Our observations encourage future research to understand the underlying molecular mechanisms and to improve treatment outcome of COVID-19. |Adult[MESH] |Aged[MESH] |Betacoronavirus/immunology[MESH] |Biomarkers/analysis[MESH] |COVID-19[MESH] |Coronavirus Infections/*diagnosis/pathology[MESH] |Cytokine Release Syndrome/blood/pathology[MESH] |Female[MESH] |Humans[MESH] |Interleukin-2 Receptor alpha Subunit/blood[MESH] |Interleukin-6/*blood[MESH] |Interleukin-8/blood[MESH] |Length of Stay/statistics & numerical data[MESH] |Lymphocyte Count/*statistics & numerical data[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*diagnosis/pathology[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Treatment Outcome[MESH]Immune characteristics distinguish patients with severe disease associ(epmc).pdf DeepDyve Pubget Overpricing