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10.1007/s00428-020-02934-1 http://scihub22266oqcxt.onion/10.1007/s00428-020-02934-1 32989525!7521863!32989525     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virchows+Arch 2021 ; 478 (3): 471-485 Nephropedia Template TP {{tp|p=32989525|t=2021. Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems |pdf=|usr=}}{{32989525}} gab.com Text Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems JO: Virchows Arch http://www.kidney.de/pget.php?&tw=1&pmid=32989525 #FOAvip Data on the pathology of COVID-19 are scarce; available studies show diffuse alveolar damage; however, there is scarce information on the chronologic evolution of COVID-19 lung lesions. The primary aim of the study is to describe the chronology of lung pathologic changes in COVID-19 by using a post-mortem transbronchial lung cryobiopsy approach. Our secondary aim is to correlate the histologic findings with computed tomography patterns. SARS-CoV-2-positive patients, who died while intubated and mechanically ventilated, were enrolled. The procedure was performed 30 min after death, and all lung lobes sampled. Histopathologic analysis was performed on thirty-nine adequate samples from eight patients: two patients (illness duration < 14 days) showed early/exudative phase diffuse alveolar damage, while the remaining 6 patients (median illness duration-32 days) showed progressive histologic patterns (3 with mid/proliferative phase; 3 with late/fibrotic phase diffuse alveolar damage, one of which with honeycombing). Immunohistochemistry for SARS-CoV-2 nucleocapsid protein was positive predominantly in early-phase lesions. Histologic patterns and tomography categories were correlated: early/exudative phase was associated with ground-glass opacity, mid/proliferative lesions with crazy paving, while late/fibrous phase correlated with the consolidation pattern, more frequently seen in the lower/middle lobes. This study uses an innovative cryobiopsy approach for the post-mortem sampling of lung tissues from COVID-19 patients demonstrating the progression of fibrosis in time and correlation with computed tomography features. These findings may prove to be useful in the correct staging of disease, and this could have implications for treatment and patient follow-up. Twit Text FOAVip Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems ????Virchows Arch http://www.kidney.de/pget.php?&tw=1&pmid=32989525 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32989525 #FOAvip English Wikipedia <ref>{{Cite pmid|32989525}}</ref> Fibrotic progression and radiologic correlation in matched lung samples from COVID-19 post-mortems #MMPMID32989525 Barisione E; Grillo F; Ball L; Bianchi R; Grosso M; Morbini P; Pelosi P; Patroniti NA; De Lucia A; Orengo G; Gratarola A; Verda M; Cittadini G; Mastracci L; Fiocca R Virchows Arch 2021[Mar]; 478 (3): 471-485 PMID32989525show ga Data on the pathology of COVID-19 are scarce; available studies show diffuse alveolar damage; however, there is scarce information on the chronologic evolution of COVID-19 lung lesions. The primary aim of the study is to describe the chronology of lung pathologic changes in COVID-19 by using a post-mortem transbronchial lung cryobiopsy approach. Our secondary aim is to correlate the histologic findings with computed tomography patterns. SARS-CoV-2-positive patients, who died while intubated and mechanically ventilated, were enrolled. The procedure was performed 30 min after death, and all lung lobes sampled. Histopathologic analysis was performed on thirty-nine adequate samples from eight patients: two patients (illness duration < 14 days) showed early/exudative phase diffuse alveolar damage, while the remaining 6 patients (median illness duration-32 days) showed progressive histologic patterns (3 with mid/proliferative phase; 3 with late/fibrotic phase diffuse alveolar damage, one of which with honeycombing). Immunohistochemistry for SARS-CoV-2 nucleocapsid protein was positive predominantly in early-phase lesions. Histologic patterns and tomography categories were correlated: early/exudative phase was associated with ground-glass opacity, mid/proliferative lesions with crazy paving, while late/fibrous phase correlated with the consolidation pattern, more frequently seen in the lower/middle lobes. This study uses an innovative cryobiopsy approach for the post-mortem sampling of lung tissues from COVID-19 patients demonstrating the progression of fibrosis in time and correlation with computed tomography features. These findings may prove to be useful in the correct staging of disease, and this could have implications for treatment and patient follow-up. |Aged[MESH] |Autopsy[MESH] |COVID-19/diagnostic imaging/*pathology/virology[MESH] |Female[MESH] |Fibrosis/diagnostic imaging/*pathology/virology[MESH] |Humans[MESH] |Lung/diagnostic imaging/pathology/virology[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*physiology[MESH]Fibrotic progression and radiologic correlation in matched lung sample(epmc).pdf DeepDyve Pubget Overpricing