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10.1126/sciimmunol.abe1670 http://scihub22266oqcxt.onion/10.1126/sciimmunol.abe1670 32989174!7857393!32989174     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Immunol 2020 ; 5 (51): ä Nephropedia Template TP {{tp|p=32989174|t=2020. MAIT cell activation and dynamics associated with COVID-19 disease severity |pdf=|usr=}}{{32989174}} gab.com Text MAIT cell activation and dynamics associated with COVID-19 disease severity JO: Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32989174 #FOAvip Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69(high) and CXCR3(low) immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis. Twit Text FOAVip MAIT cell activation and dynamics associated with COVID-19 disease severity ????Sci Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32989174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32989174 #FOAvip English Wikipedia <ref>{{Cite pmid|32989174}}</ref> MAIT cell activation and dynamics associated with COVID-19 disease severity #MMPMID32989174 Parrot T; Gorin JB; Ponzetta A; Maleki KT; Kammann T; Emgard J; Perez-Potti A; Sekine T; Rivera-Ballesteros O; Gredmark-Russ S; Rooyackers O; Folkesson E; Eriksson LI; Norrby-Teglund A; Ljunggren HG; Bjorkstrom NK; Aleman S; Buggert M; Klingstrom J; Stralin K; Sandberg JK Sci Immunol 2020[Sep]; 5 (51): ä PMID32989174show ga Severe COVID-19 is characterized by excessive inflammation of the lower airways. The balance of protective versus pathological immune responses in COVID-19 is incompletely understood. Mucosa-associated invariant T (MAIT) cells are antimicrobial T cells that recognize bacterial metabolites, and can also function as innate-like sensors and mediators of antiviral responses. Here, we investigated the MAIT cell compartment in COVID-19 patients with moderate and severe disease, as well as in convalescence. We show profound and preferential decline in MAIT cells in the circulation of patients with active disease paired with strong activation. Furthermore, transcriptomic analyses indicated significant MAIT cell enrichment and pro-inflammatory IL-17A bias in the airways. Unsupervised analysis identified MAIT cell CD69(high) and CXCR3(low) immunotypes associated with poor clinical outcome. MAIT cell levels normalized in the convalescent phase, consistent with dynamic recruitment to the tissues and later release back into the circulation when disease is resolved. These findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis. |Adult[MESH] |Aged[MESH] |Antigens, CD/metabolism[MESH] |Antigens, Differentiation, T-Lymphocyte/metabolism[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/immunology/*pathology[MESH] |Female[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Inflammation/immunology[MESH] |Interleukin-17/metabolism[MESH] |Lectins, C-Type/metabolism[MESH] |Lymphocyte Activation/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Mucosal-Associated Invariant T Cells/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/immunology/*pathology[MESH] |Receptors, CXCR3/metabolism[MESH] |SARS-CoV-2[MESH]MAIT cell activation and dynamics associated with COVID-19 disease sev(epmc).pdf DeepDyve Pubget Overpricing