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10.1016/j.jcyt.2020.08.009

http://scihub22266oqcxt.onion/10.1016/j.jcyt.2020.08.009
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32988772!7458058!32988772
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suck abstract from ncbi


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pmid32988772      Cytotherapy 2021 ; 23 (2): 101-110
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  • Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2 #MMPMID32988772
  • Sajna KV; Kamat S
  • Cytotherapy 2021[Feb]; 23 (2): 101-110 PMID32988772show ga
  • In view of devastating effects of COVID-19 on human life, there is an urgent need for the licened vaccines or therapeutics for the SARS-CoV-2 infection. Age-old passive immunization with protective antibodies to neutralize the virus is one of the strategies for emergency prophylaxis and therapy for coronavirus disease 2019 (COVID-19). In this review, the authors discuss up-to-date advances in immune-based therapy for COVID-19. The use of convalescent plasma therapy as the first line of defense to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been established, with encouraging results. Monoclonal antibodies (mAbs) that bind to the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein or block the interaction between SARS-CoV-2 RBD and the human angiotensin-converting enzyme 2 receptor have been found to be very promising as a countermeasure for tackling the SARS-CoV-2 infection, and clinical trials are underway. Considering the counterproductive antibody-dependent enhancement of the virus, mAbs therapy that is safe and efficacious, even in people with underlying conditions, will be a significant breakthrough. In addition, emerging immunotherapeutic interventions using nanobodies and cellular immunotherapy are promising avenues for tackling the COVID-19 pandemic. The authors also discuss the implication of mAbs as mediators of cytokine storm syndrome to modify the immune response of COVID-19 patients, thus reducing the fatality rate of COVID-19 infection.
  • |Antibodies, Viral/blood/*immunology[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |COVID-19/immunology/therapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Immunomodulation[MESH]
  • |Pandemics/prevention & control[MESH]


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