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10.1016/j.bja.2020.08.050

http://scihub22266oqcxt.onion/10.1016/j.bja.2020.08.050
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32988604!7833857!32988604
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suck abstract from ncbi


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pmid32988604      Br+J+Anaesth 2020 ; 125 (6): 912-925
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  • COVID-19-related organ dysfunction and management strategies on the intensive care unit: a narrative review #MMPMID32988604
  • Sherren PB; Ostermann M; Agarwal S; Meadows CIS; Ioannou N; Camporota L
  • Br J Anaesth 2020[Dec]; 125 (6): 912-925 PMID32988604show ga
  • The coronavirus disease 2019 (COVID-19) pandemic has resulted in a significant surge of critically ill patients and an unprecedented demand on intensive care services. The rapidly evolving understanding of pathogenesis, limited disease specific evidence, and demand-resource imbalances have posed significant challenges for intensive care clinicians. COVID-19 is a complex multisystem inflammatory vasculopathy with a significant mortality implication for those admitted to intensive care. Institutional strategic preparation and meticulous intensive care support are essential to maximising outcomes during the pandemic. The significant mortality variation observed between institutions and internationally, despite a single aetiology and uniform presentation, highlights the potential influence of management strategies on outcome. Given that optimal organ support and adjunctive therapies for COVID-19 have not yet been well defined by trial-based outcomes, strategies are predicated on existing literature and experiential learning. This review outlines the relevant pathophysiology and management strategies for critically ill patients with COVID-19, and shares some of the collective learning accumulated in a high volume severe respiratory failure centre in London.
  • |*Disease Management[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/*therapy[MESH]
  • |Critical Care/*methods[MESH]
  • |Humans[MESH]
  • |Multiple Organ Failure/*etiology/*therapy[MESH]
  • |Pandemics[MESH]


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