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10.1016/j.mad.2020.111363 http://scihub22266oqcxt.onion/10.1016/j.mad.2020.111363 32987038!7519013!32987038     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mech+Ageing+Dev 2020 ; 192 (ä): 111363 Nephropedia Template TP {{tp|p=32987038|t=2020. Neprilysin expression and functions in development, ageing and disease |pdf=|usr=}}{{32987038}} gab.com Text Neprilysin expression and functions in development, ageing and disease JO: Mech Ageing Dev http://www.kidney.de/pget.php?&tw=1&pmid=32987038 #FOAvip Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of substrates and physiological functions. It plays an important role in proteolytic processes in the kidney, cardiovascular regulation, immune response, cell proliferation, foetal development etc. It is an important neuropeptidase and amyloid-degrading enzyme which makes NEP a therapeutic target in Alzheimer's disease (AD). Moreover, it plays a preventive role in development of cancer, obesity and type-2 diabetes. Recently a role of NEP in COVID-19 pathogenesis has also been suggested. Despite intensive research into NEP structure and functions in different organisms, changes in its expression and regulation during brain development and ageing, especially in age-related pathologies, is still not fully understood. This prevents development of pharmacological treatments from various diseases in which NEP is implicated although recently a dual-acting drug sacubitril-valsartan (LCZ696) combining a NEP inhibitor and angiotensin receptor blocker has been approved for treatment of heart failure. Also, various natural compounds capable of upregulating NEP expression, including green tea (EGCG), have been proposed as a preventive medicine in prostate cancer and AD. This review summarizes the existing literature and our own research on the expression and activity of NEP in normal brain development, ageing and under pathological conditions. Twit Text FOAVip Neprilysin expression and functions in development, ageing and disease ????Mech Ageing Dev http://www.kidney.de/pget.php?&tw=1&pmid=32987038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32987038 #FOAvip English Wikipedia <ref>{{Cite pmid|32987038}}</ref> Neprilysin expression and functions in development, ageing and disease #MMPMID32987038 Nalivaeva NN; Zhuravin IA; Turner AJ Mech Ageing Dev 2020[Dec]; 192 (ä): 111363 PMID32987038show ga Neprilysin (NEP) is an integral membrane-bound metallopeptidase with a wide spectrum of substrates and physiological functions. It plays an important role in proteolytic processes in the kidney, cardiovascular regulation, immune response, cell proliferation, foetal development etc. It is an important neuropeptidase and amyloid-degrading enzyme which makes NEP a therapeutic target in Alzheimer's disease (AD). Moreover, it plays a preventive role in development of cancer, obesity and type-2 diabetes. Recently a role of NEP in COVID-19 pathogenesis has also been suggested. Despite intensive research into NEP structure and functions in different organisms, changes in its expression and regulation during brain development and ageing, especially in age-related pathologies, is still not fully understood. This prevents development of pharmacological treatments from various diseases in which NEP is implicated although recently a dual-acting drug sacubitril-valsartan (LCZ696) combining a NEP inhibitor and angiotensin receptor blocker has been approved for treatment of heart failure. Also, various natural compounds capable of upregulating NEP expression, including green tea (EGCG), have been proposed as a preventive medicine in prostate cancer and AD. This review summarizes the existing literature and our own research on the expression and activity of NEP in normal brain development, ageing and under pathological conditions. |Aging/*immunology/pathology[MESH] |Alzheimer Disease/*immunology/pathology[MESH] |Animals[MESH] |COVID-19/*immunology/pathology[MESH] |Diabetes Mellitus, Type 2/*immunology/pathology[MESH] |Gene Expression Regulation, Enzymologic/*immunology[MESH] |Gene Expression Regulation, Neoplastic/*immunology[MESH] |Humans[MESH] |Neoplasm Proteins/*immunology[MESH] |Neoplasms/*immunology/pathology[MESH] |Neprilysin/*immunology[MESH]Neprilysin expression and functions in development, ageing and disease(epmc).pdf DeepDyve Pubget Overpricing