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10.1093/cid/ciaa1474

http://scihub22266oqcxt.onion/10.1093/cid/ciaa1474
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suck abstract from ncbi


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pmid32986807      Clin+Infect+Dis 2021 ; 73 (7): e1762-e1765
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  • Emerging RNA-Dependent RNA Polymerase Mutation in a Remdesivir-Treated B-cell Immunodeficient Patient With Protracted Coronavirus Disease 2019 #MMPMID32986807
  • Martinot M; Jary A; Fafi-Kremer S; Leducq V; Delagreverie H; Garnier M; Pacanowski J; Mekinian A; Pirenne F; Tiberghien P; Calvez V; Humbrecht C; Marcelin AG; Lacombe K
  • Clin Infect Dis 2021[Oct]; 73 (7): e1762-e1765 PMID32986807show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly discovered virus for which remdesivir is the only antiviral available. We report the occurrence of a mutation in RdRP (D484Y) following treatment with remdesivir in a 76-year-old female with post-rituximab B-cell immunodeficiency and persistent SARS-CoV-2 viremia. A cure was achieved after supplementation with convalescent plasma.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/therapy[MESH]
  • |*RNA-Dependent RNA Polymerase[MESH]
  • |Adenosine Monophosphate/analogs & derivatives[MESH]
  • |Aged[MESH]
  • |Alanine/analogs & derivatives[MESH]
  • |B-Lymphocytes[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunization, Passive[MESH]
  • |Mutation[MESH]


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