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10.3233/JAD-200750 http://scihub22266oqcxt.onion/10.3233/JAD-200750 32986671!7683041!32986671     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Alzheimers+Dis 2020 ; 77 (4): 1805-1813 Nephropedia Template TP {{tp|p=32986671|t=2020. Managing Clinical Trials for Alzheimer s Disease During the COVID-19 Crisis: Experience at Fundacio ACE in Barcelona, Spain |pdf=|usr=}}{{32986671}} gab.com Text Managing Clinical Trials for Alzheimer s Disease During the COVID-19 Crisis: Experience at Fundacio ACE in Barcelona, Spain JO: J Alzheimers Dis http://www.kidney.de/pget.php?&tw=1&pmid=32986671 #FOAvip BACKGROUND: The COVID-19 pandemic has brought great disruption to health systems worldwide. This affected ongoing clinical research, particularly among those most vulnerable to the pandemic, like dementia patients. Fundacio ACE is a research center and memory clinic based in Barcelona, Spain, one of the hardest-hit countries. OBJECTIVE: To describe the ad-hoc strategic plan developed to cope with this crisis and to share its outcomes. METHODS: We describe participants' clinical and demographic features. Additionally, we explain our strategic plan aimed at minimizing the impact on clinical trial research activities, which included SARS-CoV-2 RT-PCR and IgG serological tests to all participants and personnel. The outcomes of the plan are described in terms of observed safety events and drop-outs during the study period. RESULTS: A total of 130 patients were participating in 16 active clinical trials in Fundacio ACE when the lockdown was established. During the confinement, we performed 1018 calls to the participants, which led to identify adverse events in 26 and COVID-19 symptoms in 6. A total of 83 patients (64%) could restart on-site visits as early as May 11, 2020. All SARS-CoV-2 RT-PCR diagnostic tests performed before on-site visits were negative and only three IgG serological tests were positive. Throughout the study period, we only observed one drop-out, due to an adverse event unrelated to COVID-19. DISCUSSION: The plan implemented by Fundacio ACE was able to preserve safety and integrity of ongoing clinical trials. We must use the lessons learned from the pandemic and design crisis-proof protocols for clinical trials. Twit Text FOAVip Managing Clinical Trials for Alzheimer s Disease During the COVID-19 Crisis: Experience at Fundacio ACE in Barcelona, Spain ????J Alzheimers Dis http://www.kidney.de/pget.php?&tw=1&pmid=32986671 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32986671 #FOAvip English Wikipedia <ref>{{Cite pmid|32986671}}</ref> Managing Clinical Trials for Alzheimer s Disease During the COVID-19 Crisis: Experience at Fundacio ACE in Barcelona, Spain #MMPMID32986671 Abdelnour C; Esteban de Antonio E; Perez-Cordon A; Lafuente A; Buendia M; Pancho A; Jofresa S; Aguilera N; Ibarria M; Cuevas R; Canada L; Calvet A; Diego S; Gonzalez-Perez A; Orellana A; Montrreal L; de Jorge L; Marquie M; Benaque A; Gurruchaga M; Tarraga L; Ruiz A; Boada M J Alzheimers Dis 2020[]; 77 (4): 1805-1813 PMID32986671show ga BACKGROUND: The COVID-19 pandemic has brought great disruption to health systems worldwide. This affected ongoing clinical research, particularly among those most vulnerable to the pandemic, like dementia patients. Fundacio ACE is a research center and memory clinic based in Barcelona, Spain, one of the hardest-hit countries. OBJECTIVE: To describe the ad-hoc strategic plan developed to cope with this crisis and to share its outcomes. METHODS: We describe participants' clinical and demographic features. Additionally, we explain our strategic plan aimed at minimizing the impact on clinical trial research activities, which included SARS-CoV-2 RT-PCR and IgG serological tests to all participants and personnel. The outcomes of the plan are described in terms of observed safety events and drop-outs during the study period. RESULTS: A total of 130 patients were participating in 16 active clinical trials in Fundacio ACE when the lockdown was established. During the confinement, we performed 1018 calls to the participants, which led to identify adverse events in 26 and COVID-19 symptoms in 6. A total of 83 patients (64%) could restart on-site visits as early as May 11, 2020. All SARS-CoV-2 RT-PCR diagnostic tests performed before on-site visits were negative and only three IgG serological tests were positive. Throughout the study period, we only observed one drop-out, due to an adverse event unrelated to COVID-19. DISCUSSION: The plan implemented by Fundacio ACE was able to preserve safety and integrity of ongoing clinical trials. We must use the lessons learned from the pandemic and design crisis-proof protocols for clinical trials. |*Clinical Trials as Topic/methods/organization & administration[MESH] |*Coronavirus Infections/diagnosis/epidemiology/prevention & control[MESH] |*Pandemics/prevention & control[MESH] |*Patient Care/methods/trends[MESH] |*Pneumonia, Viral/epidemiology/prevention & control[MESH] |Aged[MESH] |Alzheimer Disease/*therapy[MESH] |Ambulatory Care Facilities[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Clinical Laboratory Techniques[MESH] |Female[MESH] |Humans[MESH] |Male[MESH] |SARS-CoV-2[MESH] |Spain/epidemiology[MESH] |Telemedicine/methods[MESH]Managing Clinical Trials for Alzheimer s Disease During the COVID-19 C(epmc).pdf DeepDyve Pubget Overpricing