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10.3389/fonc.2020.01578

http://scihub22266oqcxt.onion/10.3389/fonc.2020.01578
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32984017!7493633!32984017
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suck abstract from ncbi

pmid32984017      Front+Oncol 2020 ; 10 (?): 1578
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  • Prolonged Course of COVID-19-Associated Pneumonia in a B-Cell Depleted Patient After Rituximab #MMPMID32984017
  • Kos I; Balensiefer B; Roth S; Ahlgrimm M; Sester M; Schmidt T; Thurner L; Bewarder M; Bals R; Lammert F; Stilgenbauer S; Kaddu-Mulindwa D
  • Front Oncol 2020[]; 10 (?): 1578 PMID32984017show ga
  • Patients with pre-existing comorbidities and immunosuppression are at greater risk for SARS-CoV-2 infection and severe manifestations of COVID-19. This also includes cancer patients, who are shown to have a poor prognosis after infection. Here, we describe the case of a 72-year old male patient with B-cell depletion after maintenance treatment with rituximab for non-Hodgkin-lymphoma who had a prolonged COVID-19 course and initial false negative test results. Our case highlights the diagnostic pitfalls in diagnosing COVID-19 in B-cell depleted patients and discuss the role of B-cell depletion in the course and treatment of COVID-19. Furthermore, we investigated peripheral blood monocytes and SARS-CoV-2 specific T cells in our patient. In conclusion, our case report can help physicians to avoid diagnostic pitfalls for COVID-19 in hemato-oncological patients under chemoimmunotherapy and tries to explain the role of B-cell depletion and SARS-CoV-2 specific T cells in this context.
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