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10.7717/peerj.9994 http://scihub22266oqcxt.onion/10.7717/peerj.9994 32983652!7497610!32983652     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PeerJ 2020 ; 8 (ä): e9994 Nephropedia Template TP {{tp|p=32983652|t=2020. Potential role of cellular miRNAs in coronavirus-host interplay |pdf=|usr=}}{{32983652}} gab.com Text Potential role of cellular miRNAs in coronavirus-host interplay JO: PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=32983652 #FOAvip Host miRNAs are known as important regulators of virus replication and pathogenesis. They can interact with various viruses through several possible mechanisms including direct binding of viral RNA. Identification of human miRNAs involved in coronavirus-host interplay becomes important due to the ongoing COVID-19 pandemic. In this article we performed computational prediction of high-confidence direct interactions between miRNAs and seven human coronavirus RNAs. As a result, we identified six miRNAs (miR-21-3p, miR-195-5p, miR-16-5p, miR-3065-5p, miR-424-5p and miR-421) with high binding probability across all analyzed viruses. Further bioinformatic analysis of binding sites revealed high conservativity of miRNA binding regions within RNAs of human coronaviruses and their strains. In order to discover the entire miRNA-virus interplay we further analyzed lungs miRNome of SARS-CoV infected mice using publicly available miRNA sequencing data. We found that miRNA miR-21-3p has the largest probability of binding the human coronavirus RNAs and being dramatically up-regulated in mouse lungs during infection induced by SARS-CoV. Twit Text FOAVip Potential role of cellular miRNAs in coronavirus-host interplay ????PeerJ http://www.kidney.de/pget.php?&tw=1&pmid=32983652 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32983652 #FOAvip English Wikipedia <ref>{{Cite pmid|32983652}}</ref> Potential role of cellular miRNAs in coronavirus-host interplay #MMPMID32983652 Nersisyan S; Engibaryan N; Gorbonos A; Kirdey K; Makhonin A; Tonevitsky A PeerJ 2020[]; 8 (ä): e9994 PMID32983652show ga Host miRNAs are known as important regulators of virus replication and pathogenesis. They can interact with various viruses through several possible mechanisms including direct binding of viral RNA. Identification of human miRNAs involved in coronavirus-host interplay becomes important due to the ongoing COVID-19 pandemic. In this article we performed computational prediction of high-confidence direct interactions between miRNAs and seven human coronavirus RNAs. As a result, we identified six miRNAs (miR-21-3p, miR-195-5p, miR-16-5p, miR-3065-5p, miR-424-5p and miR-421) with high binding probability across all analyzed viruses. Further bioinformatic analysis of binding sites revealed high conservativity of miRNA binding regions within RNAs of human coronaviruses and their strains. In order to discover the entire miRNA-virus interplay we further analyzed lungs miRNome of SARS-CoV infected mice using publicly available miRNA sequencing data. We found that miRNA miR-21-3p has the largest probability of binding the human coronavirus RNAs and being dramatically up-regulated in mouse lungs during infection induced by SARS-CoV. äPotential role of cellular miRNAs in coronavirus-host interplay (epmc).pdf DeepDyve Pubget Overpricing