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10.3389/fimmu.2020.02163 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.02163 32983181!7485091!32983181     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 2163 Nephropedia Template TP {{tp|p=32983181|t=2020. Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2 |pdf=|usr=}}{{32983181}} gab.com Text Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32983181 #FOAvip INTRODUCTION: The response to the SARS-CoV-2 coronavirus epidemic requires increased research efforts to expand our knowledge of the disease. Questions related to infection rates and mechanisms, the possibility of reinfection, and potential therapeutic approaches require us not only to use the experimental models previously employed for the SARS-CoV and MERS-CoV coronaviruses but also to generate new models to respond to urgent questions. DEVELOPMENT: We reviewed the different experimental models used in the study of central nervous system (CNS) involvement in COVID-19 both in different cell lines that have enabled identification of the virus' action mechanisms and in animal models (mice, rats, hamsters, ferrets, and primates) inoculated with the virus. Specifically, we reviewed models used to assess the presence and effects of SARS-CoV-2 on the CNS, including neural cell lines, animal models such as mouse hepatitis virus CoV (especially the 59 strain), and the use of brain organoids. CONCLUSION: Given the clear need to increase our understanding of SARS-CoV-2, as well as its potential effects on the CNS, we must endeavor to obtain new information with cellular or animal models, with an appropriate resemblance between models and human patients. Twit Text FOAVip Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32983181 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32983181 #FOAvip English Wikipedia <ref>{{Cite pmid|32983181}}</ref> Experimental Models for the Study of Central Nervous System Infection by SARS-CoV-2 #MMPMID32983181 Sanclemente-Alaman I; Moreno-Jimenez L; Benito-Martin MS; Canales-Aguirre A; Matias-Guiu JA; Matias-Guiu J; Gomez-Pinedo U Front Immunol 2020[]; 11 (ä): 2163 PMID32983181show ga INTRODUCTION: The response to the SARS-CoV-2 coronavirus epidemic requires increased research efforts to expand our knowledge of the disease. Questions related to infection rates and mechanisms, the possibility of reinfection, and potential therapeutic approaches require us not only to use the experimental models previously employed for the SARS-CoV and MERS-CoV coronaviruses but also to generate new models to respond to urgent questions. DEVELOPMENT: We reviewed the different experimental models used in the study of central nervous system (CNS) involvement in COVID-19 both in different cell lines that have enabled identification of the virus' action mechanisms and in animal models (mice, rats, hamsters, ferrets, and primates) inoculated with the virus. Specifically, we reviewed models used to assess the presence and effects of SARS-CoV-2 on the CNS, including neural cell lines, animal models such as mouse hepatitis virus CoV (especially the 59 strain), and the use of brain organoids. CONCLUSION: Given the clear need to increase our understanding of SARS-CoV-2, as well as its potential effects on the CNS, we must endeavor to obtain new information with cellular or animal models, with an appropriate resemblance between models and human patients. |*Betacoronavirus[MESH] |*Disease Models, Animal[MESH] |Animals[MESH] |COVID-19[MESH] |Cell Line, Tumor[MESH] |Central Nervous System Infections/*complications/*immunology/virology[MESH] |Coronavirus Infections/*complications/*immunology/virology[MESH] |Cricetinae[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Mice[MESH] |Organoids[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*immunology/virology[MESH]Experimental Models for the Study of Central Nervous System Infection (epmc).pdf DeepDyve Pubget Overpricing