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10.3389/fimmu.2020.02147 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.02147 32983176!7485092!32983176     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2020 ; 11 (ä): 2147 Nephropedia Template TP {{tp|p=32983176|t=2020. What s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses |pdf=|usr=}}{{32983176}} gab.com Text What s Sex Got to Do With COVID-19 Gender-Based Differences in the Host Immune Response to Coronaviruses JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32983176 #FOAvip The novel severe acute respiratory syndrome coronavirus 2, the cause of the coronavirus disease 2019 (COVID-19) pandemic, has ravaged the world, with over 22 million total cases and over 770,000 deaths worldwide as of August 18, 2020. While the elderly are most severely affected, implicating an age bias, a striking factor in the demographics of this deadly disease is the gender bias, with higher numbers of cases, greater disease severity, and higher death rates among men than women across the lifespan. While pre-existing comorbidities and social, behavioral, and lifestyle factors contribute to this bias, biological factors underlying the host immune response may be crucial contributors. Women mount stronger immune responses to infections and vaccinations and outlive men. Sex-based biological factors underlying the immune response are therefore important determinants of susceptibility to infections, disease outcomes, and mortality. Despite this, gender is a profoundly understudied and often overlooked variable in research related to the immune response and infectious diseases, and it is largely ignored in drug and vaccine clinical trials. Understanding these factors will not only help better understand the pathogenesis of COVID-19, but it will also guide the design of effective therapies and vaccine strategies for gender-based personalized medicine. This review focuses on sex-based differences in genes, sex hormones, and the microbiome underlying the host immune response and their relevance to infections with a focus on coronaviruses. Twit Text FOAVip What s Sex Got to Do With COVID-19 Gender-Based Differences in the Host Immune Response to Coronaviruses ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32983176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32983176 #FOAvip English Wikipedia <ref>{{Cite pmid|32983176}}</ref> What s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses #MMPMID32983176 Gadi N; Wu SC; Spihlman AP; Moulton VR Front Immunol 2020[]; 11 (ä): 2147 PMID32983176show ga The novel severe acute respiratory syndrome coronavirus 2, the cause of the coronavirus disease 2019 (COVID-19) pandemic, has ravaged the world, with over 22 million total cases and over 770,000 deaths worldwide as of August 18, 2020. While the elderly are most severely affected, implicating an age bias, a striking factor in the demographics of this deadly disease is the gender bias, with higher numbers of cases, greater disease severity, and higher death rates among men than women across the lifespan. While pre-existing comorbidities and social, behavioral, and lifestyle factors contribute to this bias, biological factors underlying the host immune response may be crucial contributors. Women mount stronger immune responses to infections and vaccinations and outlive men. Sex-based biological factors underlying the immune response are therefore important determinants of susceptibility to infections, disease outcomes, and mortality. Despite this, gender is a profoundly understudied and often overlooked variable in research related to the immune response and infectious diseases, and it is largely ignored in drug and vaccine clinical trials. Understanding these factors will not only help better understand the pathogenesis of COVID-19, but it will also guide the design of effective therapies and vaccine strategies for gender-based personalized medicine. This review focuses on sex-based differences in genes, sex hormones, and the microbiome underlying the host immune response and their relevance to infections with a focus on coronaviruses. |Adaptive Immunity/genetics[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/*mortality/virology[MESH] |Female[MESH] |Genetic Predisposition to Disease[MESH] |Gonadal Steroid Hormones/immunology[MESH] |Host-Pathogen Interactions/genetics/*immunology[MESH] |Humans[MESH] |Immunity, Innate/genetics[MESH] |Male[MESH] |Microbiota/immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/*mortality/virology[MESH] |SARS-CoV-2[MESH]What s Sex Got to Do With COVID-19? Gender-Based Differences in the Ho(epmc).pdf DeepDyve Pubget Overpricing