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10.3389/fimmu.2020.02145 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.02145 32983174!7485000!32983174     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32983174.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2020 ; 11 (ä): 2145 Nephropedia Template TP {{tp|p=32983174|t=2020. Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19 |pdf=|usr=}}{{32983174}} gab.com Text Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32983174 #FOAvip SARS-CoV-2 infection has recently been declared a pandemic. Some patients showing severe symptoms exhibit drastic inflammation and airway damage. In this study, we re-analyzed published scRNA-seq data of COVID-19 patient bronchoalveolar lavage fluid to further classify and compare immunological features according to the patient's disease severity. Patients with severe symptoms showed DNA damage and apoptotic features of epithelial cells. Our results suggested that epithelial damage was associated with neutrophil infiltration. Myeloid cells of severe patients showed higher expression of proinflammatory cytokines and chemokines such as CXCL8. As a result, neutrophils were abundant in lungs of patients from the severe group. Furthermore, recruited neutrophils highly expressed genes related to neutrophil extracellular traps. Neutrophil-mediated inflammation was regulated by glucocorticoid receptor expression and activity. Based on these results, we suggest that severe COVID-19 symptoms may be determined by differential expression of glucocorticoid receptors and neutrophils. Twit Text FOAVip Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32983174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32983174 #FOAvip English Wikipedia <ref>{{Cite pmid|32983174}}</ref> Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19 #MMPMID32983174 Park JH; Lee HK Front Immunol 2020[]; 11 (ä): 2145 PMID32983174show ga SARS-CoV-2 infection has recently been declared a pandemic. Some patients showing severe symptoms exhibit drastic inflammation and airway damage. In this study, we re-analyzed published scRNA-seq data of COVID-19 patient bronchoalveolar lavage fluid to further classify and compare immunological features according to the patient's disease severity. Patients with severe symptoms showed DNA damage and apoptotic features of epithelial cells. Our results suggested that epithelial damage was associated with neutrophil infiltration. Myeloid cells of severe patients showed higher expression of proinflammatory cytokines and chemokines such as CXCL8. As a result, neutrophils were abundant in lungs of patients from the severe group. Furthermore, recruited neutrophils highly expressed genes related to neutrophil extracellular traps. Neutrophil-mediated inflammation was regulated by glucocorticoid receptor expression and activity. Based on these results, we suggest that severe COVID-19 symptoms may be determined by differential expression of glucocorticoid receptors and neutrophils. |*Severity of Illness Index[MESH] |*Transcriptome[MESH] |Adult[MESH] |Aged[MESH] |Betacoronavirus/*immunology[MESH] |Bronchoalveolar Lavage Fluid/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/virology[MESH] |Epithelial Cells/pathology[MESH] |Extracellular Traps/immunology[MESH] |Female[MESH] |Gene Expression Profiling/methods[MESH] |Humans[MESH] |Inflammation/immunology[MESH] |Interleukin-8/*genetics/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloid Cells/immunology[MESH] |Neutrophil Infiltration/immunology[MESH] |Neutrophils/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/virology[MESH] |RNA-Seq[MESH] |Receptors, Glucocorticoid/*genetics/metabolism[MESH] |SARS-CoV-2[MESH]Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-(epmc).pdf DeepDyve Pubget Overpricing