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10.1253/circj.CJ-20-0881 http://scihub22266oqcxt.onion/10.1253/circj.CJ-20-0881 32981925!?!32981925       Circ+J 2020 ; 84 (11): 2027-2031 Nephropedia Template TP {{tp|p=32981925|t=2020. Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury |pdf=|usr=}}{{32981925}} gab.com Text Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury JO: Circ J http://www.kidney.de/pget.php?&tw=1&pmid=32981925 #FOAvip BACKGROUND: SARS-CoV-2 infection is associated with myocardial injury, but there is a paucity of experimental platforms for the condition. METHODS AND RESULTS: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) infected by SARS-CoV-2 for 3 days ceased beating and exhibited cytopathogenic changes with reduced viability. Active viral replication was evidenced by an increase in supernatant SARS-CoV-2 and the presence of SARS-CoV-2 nucleocaspid protein within hiPSC-CMs. Expressions of BNP, CXCL1, CXCL2, IL-6, IL-8 and TNF-alpha were upregulated, while ACE2 was downregulated. CONCLUSIONS: Our hiPSC-CM-based in-vitro SARS-CoV-2 myocarditis model recapitulated the cytopathogenic effects and cytokine/chemokine response. It could be exploited as a drug screening platform. Twit Text FOAVip Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury ????Circ J http://www.kidney.de/pget.php?&tw=1&pmid=32981925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32981925 #FOAvip English Wikipedia <ref>{{Cite pmid|32981925}}</ref> Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to Study SARS-CoV-2 Related Myocardial Injury #MMPMID32981925 Wong CK; Luk HK; Lai WH; Lau YM; Zhang RR; Wong AC; Lo GC; Chan KH; Hung IF; Tse HF; Woo PC; Lau SK; Siu CW Circ J 2020[Oct]; 84 (11): 2027-2031 PMID32981925show ga BACKGROUND: SARS-CoV-2 infection is associated with myocardial injury, but there is a paucity of experimental platforms for the condition. METHODS AND RESULTS: Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) infected by SARS-CoV-2 for 3 days ceased beating and exhibited cytopathogenic changes with reduced viability. Active viral replication was evidenced by an increase in supernatant SARS-CoV-2 and the presence of SARS-CoV-2 nucleocaspid protein within hiPSC-CMs. Expressions of BNP, CXCL1, CXCL2, IL-6, IL-8 and TNF-alpha were upregulated, while ACE2 was downregulated. CONCLUSIONS: Our hiPSC-CM-based in-vitro SARS-CoV-2 myocarditis model recapitulated the cytopathogenic effects and cytokine/chemokine response. It could be exploited as a drug screening platform. |Angiotensin-Converting Enzyme 2[MESH] |Betacoronavirus/genetics/*metabolism[MESH] |COVID-19[MESH] |Cell Survival[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/*complications/metabolism/virology[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Cytokines/metabolism[MESH] |Cytopathogenic Effect, Viral[MESH] |Drug Evaluation, Preclinical/methods[MESH] |Humans[MESH] |Induced Pluripotent Stem Cells/metabolism/*virology[MESH] |Myocarditis/*complications/metabolism/virology[MESH] |Myocytes, Cardiac/metabolism/*virology[MESH] |Nucleocapsid Proteins/metabolism[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Phosphoproteins[MESH] |Pneumonia, Viral/*complications/metabolism/virology[MESH] |Reverse Transcriptase Polymerase Chain Reaction[MESH] |SARS-CoV-2[MESH]Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Platform to(epmc).pdf DeepDyve Pubget Overpricing