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10.1248/yakushi.20-00169 http://scihub22266oqcxt.onion/10.1248/yakushi.20-00169 32981902!ä!32981902 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538 Warning: Undefined variable $yww in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 538       Yakugaku+Zasshi 2020 ; 140 (12): 1495-1500 Nephropedia Template TP {{tp|p=32981902|t=2020. Evaluation of Valved Holding Chambers Simulating Repurposing Use of Ciclesonide Metered-dose Inhaler by Patients with Pneumonia |pdf=|usr=}}{{32981902}} gab.com Text Evaluation of Valved Holding Chambers Simulating Repurposing Use of Ciclesonide Metered-dose Inhaler by Patients with Pneumonia JO: Yakugaku Zasshi http://www.kidney.de/pget.php?&tw=1&pmid=32981902 #FOAvip Achieving appropriate inhalation in patients with coronavirus disease 2019 (COVID-19) is a common challenge in the use of repurposed metered-dose inhaler (MDI) formulations. The purpose of this study was to evaluate the effect of five valved holding chambers (VHCs) on the inhalation of ciclesonide from Alvesco MDI. The aerodynamic particle size distribution of ciclesonide discharged from Alvesco MDI was evaluated using a Next Generation Impactor in the presence and absence of VHCs. The use of VHCs retained or slightly increased the amount of ciclesonide in the fine particle diameter range (aerodynamic particle size below 3 mum) (FPD) and reduced the amount at the induction port after coordinated inhalation. However, the use of VHC reduced the FPD of the formulation by increasing the time between the MDI discharge and the pump suction by various degrees among the five VHCs. These results indicated that use of the VHCs and minimizing the inhalation delay time should ensure sufficient inhalation of ciclesonide particles. Twit Text FOAVip Evaluation of Valved Holding Chambers Simulating Repurposing Use of Ciclesonide Metered-dose Inhaler by Patients with Pneumonia ????Yakugaku Zasshi http://www.kidney.de/pget.php?&tw=1&pmid=32981902 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32981902 #FOAvip English Wikipedia <ref>{{Cite pmid|32981902}}</ref> Evaluation of Valved Holding Chambers Simulating Repurposing Use of Ciclesonide Metered-dose Inhaler by Patients with Pneumonia #MMPMID32981902 Yoshida H; Abe Y; Usui A; Izutsu KI Yakugaku Zasshi 2020[Dec]; 140 (12): 1495-1500 PMID32981902show ga Achieving appropriate inhalation in patients with coronavirus disease 2019 (COVID-19) is a common challenge in the use of repurposed metered-dose inhaler (MDI) formulations. The purpose of this study was to evaluate the effect of five valved holding chambers (VHCs) on the inhalation of ciclesonide from Alvesco MDI. The aerodynamic particle size distribution of ciclesonide discharged from Alvesco MDI was evaluated using a Next Generation Impactor in the presence and absence of VHCs. The use of VHCs retained or slightly increased the amount of ciclesonide in the fine particle diameter range (aerodynamic particle size below 3 mum) (FPD) and reduced the amount at the induction port after coordinated inhalation. However, the use of VHC reduced the FPD of the formulation by increasing the time between the MDI discharge and the pump suction by various degrees among the five VHCs. These results indicated that use of the VHCs and minimizing the inhalation delay time should ensure sufficient inhalation of ciclesonide particles. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |*Inhalation Spacers[MESH] |*Metered Dose Inhalers[MESH] |Administration, Inhalation[MESH] |Humans[MESH] |Particle Size[MESH] Evaluation of Valved Holding Chambers Simulating Repurposing Use of C(epmc).pdf DeepDyve Pubget Overpricing