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10.1016/j.hrtlng.2020.08.025

http://scihub22266oqcxt.onion/10.1016/j.hrtlng.2020.08.025
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suck abstract from ncbi


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pmid32980626      Heart+Lung 2020 ; 49 (6): 763-773
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  • COVID-19 outbreak: Challenges in pharmacotherapy based on pharmacokinetic and pharmacodynamic aspects of drug therapy in patients with moderate to severe infection #MMPMID32980626
  • Ghasemiyeh P; Mohammadi-Samani S
  • Heart Lung 2020[Nov]; 49 (6): 763-773 PMID32980626show ga
  • The new coronavirus (COVID-19) was first detected in Wuhan city of China in December 2019. Most patients infected with COVID-19 had clinical presentations of dry cough, fever, dyspnea, chest pain, fatigue and malaise, pneumonia, and bilateral infiltration in chest CT. Soon COVID-19 was spread around the world and became a pandemic. Now many patients around the world are suffering from this disease. Patients with predisposing diseases are highly prone to COVID-19 and manifesting severe infection especially with organ function damage such as acute respiratory distress syndrome, acute kidney injury, septic shock, ventilator-associated pneumonia, and death. Till now many drugs have been considered in the treatment of COVID-19 pneumonia, but pharmacotherapy in elderly patients and patients with pre-existing comorbidities is highly challenging. In this review, different potential drugs which have been considered in COVID-19 treatment have been discussed in detail. Also, challenges in the pharmacotherapy of COVID-19 pneumonia in patients with the underlying disease have been considered based on pharmacokinetic and pharmacodynamic aspects of these drugs.
  • |*Antiviral Agents/pharmacokinetics/pharmacology/therapeutic use[MESH]
  • |*Coronavirus Infections/drug therapy/epidemiology/physiopathology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/drug therapy/epidemiology/physiopathology[MESH]
  • |Aged[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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