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10.1016/j.cell.2020.08.017 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.08.017 32979941!7427556!32979941     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 183 (1): 158-168.e14 Nephropedia Template TP {{tp|p=32979941|t=2020. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 |pdf=|usr=}}{{32979941}} gab.com Text Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32979941 #FOAvip SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. Twit Text FOAVip Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32979941 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32979941 #FOAvip English Wikipedia <ref>{{Cite pmid|32979941}}</ref> Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 #MMPMID32979941 Sekine T; Perez-Potti A; Rivera-Ballesteros O; Stralin K; Gorin JB; Olsson A; Llewellyn-Lacey S; Kamal H; Bogdanovic G; Muschiol S; Wullimann DJ; Kammann T; Emgard J; Parrot T; Folkesson E; Rooyackers O; Eriksson LI; Henter JI; Sonnerborg A; Allander T; Albert J; Nielsen M; Klingstrom J; Gredmark-Russ S; Bjorkstrom NK; Sandberg JK; Price DA; Ljunggren HG; Aleman S; Buggert M Cell 2020[Oct]; 183 (1): 158-168.e14 PMID32979941show ga SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. Here, we systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute-phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent-phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits broadly directed and functionally replete memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19. |*Convalescence[MESH] |Adult[MESH] |Antibodies, Viral/immunology[MESH] |Asymptomatic Infections[MESH] |Betacoronavirus/immunology[MESH] |COVID-19[MESH] |Coronavirus Infections/*immunology/pathology[MESH] |Female[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/pathology[MESH] |SARS-CoV-2[MESH]Robust T Cell Immunity in Convalescent Individuals with Asymptomatic o(epmc).pdf DeepDyve Pubget Overpricing